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US 12,233,062 B2Granted
Heterocyclic derivatives useful as SHP2 inhibitors
AssigneeJacobio Pharmaceuticals Co., Ltd.
InventorsHuifeng Han, Panliang Gao, Cunbo Ma, Di Kang
Life of this patent
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Abstract
This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.
Claims11
A compound of Formula II:
- II;
- or a pharmaceutically acceptable salt thereof;
- wherein:
- represents a single bond or a double bond;
- ring A is
- ring B is
- wherein * represents the connection point to G and ** represents the connection point to N;
- G is S;
- T is CR1R2;
- each of R1 and R2 is independently selected from hydrogen, deuterium, or —NH2;
- p is 1;
- each of R3 and R4 is independently hydrogen or deuterium;
- q is 1;
- W is absent;
- Y5 is C;
- Y6 is C;
- ring C is
- Ra is H;
- and
- n is 0.
17 more elements
A compound which is:
- (S)-1-amino-1′-(6-((3-amino-2-chlorophenyl)thio)-1,2,4-triazin-3-yl)-1,3-dihydrospiro [indene-2,4′-piperidine]-6-carbonitrile;
- or
- (S)-1′-(5-amino-6-((2-amino-3-chloropyridin-4-yl)thio)-1,2,4-triazin-3-yl)-5,7-dihydrospiro [cyclopenta [b]pyridine-6,4′-piperidin]-5-amine;
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.