Methods, devices, and systems for physiological parameter analysis

A system for improving glucose management of a subject by adjusting a glucose level target, the system comprising:

• one or more processors;
• and
• a memory operatively coupled to the one or more processors and having instructions stored thereon which, when executed by the one or more processors, causes the one or more processors to:
• receive a plurality of first glucose levels in a bodily fluid over a first time period for the subject from an analyte sensor configured to measure the glucose level in a bodily fluid;
• receive a first glycated hemoglobin (HbA1lc) level for the subject corresponding to an end of the first time period;
• receive a reticulocyte production index (RPI) value for the subject;
• determine a red blood cell elimination constant (kage) based on the RPI value;
• determine at least one physiological parameter selected from the group consisting of:
• a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), and an apparent glycation constant (K), based on (1) the plurality of first glucose levels, (2) the first HbA1c level, and kage;
• adjust a glucose level target based on the at least one physiological parameter;
• display the adjusted glucose level target;
• and
• treat the subject based on a comparison of the adjusted glucose level target to a current glucose level of the subject, wherein the treat the subject comprises administer and/or adjust:
• an insulin dosage, a glycation medication dosage, or a combination thereof.