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US 12,228,568 B2Granted
Redox-labile fluorescent probes and their surface immobilization methods for the detection of metabolites
AssigneeThe Regents of the University of California
InventorsWei Wei, Min Xue, Zhonghan Li, Hanjun Cheng
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Abstract
Disclosed herein is an analytical method for profiling lactate (or other analyte) production in single cells, via the use of coupled enzyme reactions on surface-grafted resazurin/resorufin molecules is provided. Additionally surface-bound resazurin/resorufin that retains redox indicator activity as well as microfluidic devices comprising such surface-bound resazurin/resorufin indicators are provided.
Claims23
A compound, which has a redox-active resazurin moiety, wherein said compound is selected from the group consisting of
- wherein n is 2 to 24;
- wherein j and k are independently 2-46;
- and
Dependencies are inferred from the claim text.