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US 12,228,566 B2Granted
System and method for protein corona sensor array for early detection of diseases
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsOmid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Abstract
The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
Claims20
A method of identifying a pattern of protein biomarkers from a biological fluid, wherein the method comprises:
- a. incubating magnetic particles that differ from each other in at least one physicochemical property with the biological fluid from a subject in a disease state to allow biomolecule coronas to form on surfaces of the magnetic particles, and wherein the pattern of protein biomarkers of the biomolecule coronas differs based on the different physicochemical properties of the magnetic particles;
- b. isolating the magnetic particles and the biomolecule coronas;
- and
- c. analyzing proteins of the biomolecule coronas by mass spectrometry to identify a relationship between a protein biomarker in the pattern of protein biomarkers and the disease state, wherein the analysis is performed at least in part using a computer.
1 more element
Dependencies are inferred from the claim text.