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US 12,227,595 B2Granted
Anti-renalase antibodies for the treatment and prevention of diseases and disorders
AssigneeYale University
InventorsGary Desir, Bryce Nelson
Life of this patent
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Abstract
The present invention relates to compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules may act as therapeutics.
Claims11
A composition comprising an antibody or binding portion thereof that specifically binds to renalase, wherein the antibody or binding portion thereof comprises:
- a) a heavy chain (HC) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 191, b) a HC CDR2 comprising the amino acid sequence of SEQ ID NO:
- 192, c) a HC CDR3 comprising the amino acid sequence of SEQ ID NO:
- 193, d) a light chain (LC) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 188, e) a LC CDR2 comprising the amino acid sequence of SEQ ID NO:
- 189, and f) a LC CDR3 comprising the amino acid sequence of SEQ ID NO:
- 190.
4 more elements
Dependencies are inferred from the claim text.