US 12,227,592 B2 · Monoclonal antibody specifically binding to CCSP-2 and use thereof

Abstract

The present invention relates to a monoclonal antibody which specifically binds to an EGF2 domain of colon cancer secreted protein-2 (CCSP-2), or an antigen-binding fragment thereof. The monoclonal antibody or the antigen-binding fragment thereof of the present invention specifically binds to the EGF2 domain of CCSP-2, and thus has significantly increased affinity compared with existing peptides specifically binding to CCSP-2 and further increased specificity compared with existing antibodies to CCSP-2. Therefore, in future, accurate diagnosis can be achieved by specific detection of CCSP-2 in the protein level.

Claims8

Dependent claims

A monoclonal antibody specifically binding to the EGF2 domain of colon cancer secreted protein-2 (CCSP-2), which comprises heavy chain CDR1, 2, and 3 and light chain CDR1, 2, and 3,

wherein 1) the heavy chain CDR1, 2, and 3 comprises the amino acid sequence of SEQ ID NOs:
1, 2 and 3 respectively, and the light chain CDR1, 2, and 3 comprises the amino acid sequence of SEQ ID NOs:
4, 5, and 6 respectively, or
2) the heavy chain CDR1, 2, and 3 comprises the amino acid sequence of SEQ ID NOs:
13, 14, and 15 respectively, and the light chain CDR1, 2, and 3 comprises the amino acid sequence of SEQ ID NOs:
16, 17, and 18 respectively.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/310,296Filed 29 Jan 2020

Priority

KR 10-2019-001117229 Jan 2019

Published

US 2022/0089774 A124 Mar 2022

Granted

18 Feb 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07K 16/32
Against material from animals or humans: against translation products of oncogenes
G01N 33/57535
For cancer: of the large intestine, e.g. colon, rectum or anus
C07K 16/22
Against material from animals or humans: against growth factors ; against growth regulators
C07K 16/30
Against receptors, cell surface antigens or cell surface determinants: from tumour cells

Monoclonal antibody specifically binding to CCSP-2 and use thereof

Life of this patent

Monoclonal antibody specifically binding to CCSP-2 and use thereof

Life of this patent

Abstract

Claims8