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US 12,227,542 B2Granted
Method for producing peptide compound, protective group-forming reagent, and condensed polycyclic compound
AssigneeFUJIFILM Corporation
InventorsYosuke Yamamoto, Makoto Takahashi
Life of this patent
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Abstract
Provided are a method for producing a peptide compound including a step of using a compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. At least one of R1 to R8 or Y2 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more. However, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
Claims7
A method for producing a peptide compound, comprising:
- a step of using a compound represented by Formula (1),
- in Formula (1),
- Y1 represents —SH, Br, Cl, —OH, —NH2, —NHEt, where Et represents an ethyl group, or —NHFmoc, where Fmoc represents a 9-fluorenylmethoxycarbonyl group,
- Y2 represents —O—, —S—, —CH═CH—, —C(CH3)═C(CH3)—, —CH2—CH2—, —C(CH3)2—,
- R1, R2, R5, R7, and R8 each represent a hydrogen atom,
- R3 represents a hydrogen atom,
- —OC22H45, or —OC12H24OC22H45,
- R4 represents a hydrogen atom or —NH2,
- R6 represents a hydrogen atom,
- —OC22H45, or —OC12H24OC22H45,
- provided that at least one of the following (i), (ii), or (iii) is satisfied:
- (i) Y2 represents
- (ii) R3 represents
- —OC22H45, or —OC12H24OC22H45;
- or
- (iii) R6 represents
- —OC22H45, or —OC12H24OC22H45.
14 more elements
Dependencies are inferred from the claim text.