1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide as anti-tubercular agents
AssigneeKing Faisal University
InventorsKatharigatta N. Venugopala, Melendran Pillay, Pran Kishore Deb, Mohamed A. Morsy, Sandeep Chandrashekarappa, Bandar Aldhubiab
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Abstract
Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.
Claims5
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R1 is selected from the group consisting of Br and F.
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
- 1-(2-(4-Bromophenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide (3b);
- 1-(2-(4-Fluorophenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide (3d);
- and
- a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.
Dependencies are inferred from the claim text.