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US 12,227,472 B2Granted
Series of skin-whitening (lightening) compounds
AssigneeUnigen, Inc.
InventorsSandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe Arrachchigae Papmapiya
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Abstract
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Claims4
A composition comprising the compound of Formula V:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H or C1-C10 alkyl;
- Bn is a benzyl;
- and
- R′ is 1 to 3 moieties (R′, R″, R′″) independently selected from the group consisting of a C1-C10 alkyl group, a C1-C10 alkoxy group or a hydroxyl group;
- and
- a pharmaceutically or cosmetically acceptable carrier.
4 more elements
Dependencies are inferred from the claim text.