Systems and methods for producing a mixer
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsTrinh Vo, Huyun Chen, Amardeep Singh Bhupender Bhalla
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Abstract
Systems and method for producing a small-scale mixer are provided. In some implementations, a method for includes obtaining dimensions of an at-scale mixer. The method also includes determining first dimensions of the small-scale mixer based on respective dimensions of the at-scale mixer. The method further includes determining second dimensions of the small-scale mixer independent of the dimensions of the at-scale mixer. Additionally, the method includes generating the small-scale mixer using the first dimensions and the second dimensions using a three-dimensional printer.
Claims20
A system for producing a first mixer for mixing biopharmaceutical proteins into an aqueous formulation, the system comprising:
- a first plurality of dimensions based on a respective plurality of dimensions of a second mixer;
- a second plurality of dimensions independent of the respective plurality of dimensions of the second mixer, wherein the second plurality of dimensions is generated by a computational fluid dynamic technique simulating physical forces on an impeller and shear forces on the biopharmaceutical proteins in the aqueous formulation by the impeller over various rotational velocities, fluid densities, and temperatures, and wherein the second plurality of dimensions are calculated to prevent degradation of the biopharmaceutical proteins in the aqueous formulation;
- a three-dimensional printer configured to receive the first plurality of dimensions and the second plurality of dimensions and produce the first mixer, wherein the first mixer has a plurality of dimensions based on a combination of the first plurality of dimensions and the second plurality of dimensions;
- and
- a smoothing apparatus configured to smooth a surface of the first mixer, wherein smoothing the surface of the first mixer prevents degradation of the biopharmaceutical proteins in the aqueous formulation.
A method for producing a first mixer for mixing biopharmaceutical proteins into an aqueous formulation, the method comprising:
- obtaining a respective plurality of dimensions of a second mixer;
- determining a first plurality of dimensions of the first mixer based on the respective plurality of dimensions of the second mixer;
- determining, by simulating physical forces on an impeller and shear forces on the biopharmaceutical proteins in the aqueous formulation by the impeller over various rotational velocities, fluid densities, and temperatures generated by the first mixer using a computational fluid dynamics technique, a second plurality of dimensions independent of the plurality of dimensions of the second mixer, wherein the second plurality of dimensions are calculated to prevent degradation of the biopharmaceutical proteins in the aqueous formulation;
- and
- generating, using a three-dimensional printer, the first mixer having a plurality of dimensions based on a combination of the first plurality of dimensions and the second plurality of dimensions.
Dependencies are inferred from the claim text.