# US 12,226,615 B2 · Method and device for the needle-free injecting of fluid into a substrate > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,226,615 B2 - Document ID: US12226615B2 - Status: Granted - Kind: B2 - Application number: 16/762,198 - Filed: 2018-11-09 - Published: 2020-11-12 - Granted: 2025-02-18 - Earliest claimed: 2017-11-10 - Assignees: Conzima GmbH - Applicants: Conzima GmbH - Inventors: Fritz Schmitt - Web page: https://patentgrep.com/patent/US12226615B2 ## CPC - A61M 5/3007: {with specially designed jet passages at the injector's distal end} - A61M 5/31583: {the piston rod being moved by the rotational movement of a component directly in contact with it} - A61M 2005/2407: {from the rear} - A61M 2005/247: {with fixed or steady piercing means, e.g. piercing under movement of ampoule} - A61M 2005/31588: {electrically driven} - A61M 2205/8206: battery-operated - A61M 2205/8262: connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter - A61M 2205/8287: operated by an external magnetic or electromagnetic field - A61M 2250/00: Specially adapted for animals - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A method and a device for needleless injection of liquid into a substrate, in particular of a liquid pharmaceutical or cosmetic preparation into a biological tissue, which makes it possible in a particularly advantageous manner to reliably inject a particularly fine liquid jet into the substrate without a significant increase in the static pressure in the liquid during the injection process. According to the invention, this is achieved by first accelerating the liquid received in a liquid container together with the latter to an initial velocity before the movement of the liquid container is stopped again, while simultaneously ejecting the liquid from the liquid container through an outlet nozzle under at least partial retention of its movement. Preferably, the ejected liquid jet is set in rotation about its jet axis before it impinges on the substrate, so that the jet receives a helical movement and thus practically drills into the substrate without splashing away laterally. ## Claims ### Claim 1 A method for needleless injection of liquid into a substrate, in particular a liquid, pharmaceutical or cosmetic product into a biological tissue, in which the liquid is ejected from a liquid container and through an outlet nozzle and exits this outlet nozzle at a high ejection velocity as a liquid jet which enters the substrate, wherein a plunger and the liquid container together with the liquid contained therein are all continuously accelerated in their entirety from a first position away from the outlet nozzle to an initial velocity and then the liquid container is stopped adjacent to the outlet nozzle, with the continuous acceleration generating sufficient force that the liquid continues to move at a high velocity sufficient to initially eject a first partial quantity of liquid from the container through the outlet nozzle into the substrate, with the plunger thereafter travelling towards the outlet nozzle at a lower velocity to eject a remaining second partial quantity of liquid from the container into the substrate. ### Claim 2 (depends on 1) The method according to claim 1, wherein, before and/or while passing through the outlet nozzle, the liquid jet is set in rotation about its jet axis at least on its outer circumference. ### Claim 3 An injection device for needleless injection of liquid into a substrate, in particular of a liquid, pharmaceutical or cosmetic product into a biological tissue, comprising a housing for accommodating a liquid container containing the liquid and an ejector device including a plunger for ejecting the liquid from the liquid container through an outlet nozzle, an acceleration device for continuously accelerating the plunger and the liquid container with the liquid contained therein in their entirety from a first position away from the outlet nozzle to an initial velocity inside the housing and a deceleration device adjacent the outlet nozzle for stopping the movement of the liquid container, wherein the acceleration device is configured to generate sufficient force that the liquid continues to move at a sufficient high velocity to eject a first partial quantity of liquid from the container through the outlet nozzle into the substrate, with the plunger thereafter configured to travel towards the outlet nozzle at a lower velocity to eject a remaining second partial quantity of liquid from the container into the substrate. ### Claim 4 (depends on 3) The injection device according to claim 3, wherein the acceleration device comprises a pressure piece arranged on or acting on a rear of the liquid container opposite the outlet nozzle, wherein the pressure piece is acceleratable together with the liquid container and the liquid contained therein in the housing to the initial velocity by means of the ejector device. ### Claim 5 (depends on 4) The injection device according to claim 4, wherein the liquid container has a cylinder space containing the liquid, into which the pressure piece is insertable. ### Claim 6 (depends on 5) The injection device according to claim 5, wherein the liquid container has an acceleration zone which converges from a cross-section of the cylinder space towards an inlet cross-section of the outlet nozzle. ### Claim 7 (depends on 3) The injection device according to claim 3, wherein the deceleration device is substantially formed by a stop acting between the housing and the liquid container. ### Claim 8 (depends on 7) The injection device according to claim 7, wherein the stop is provided with a stop damper. ### Claim 9 (depends on 3) The injection device according to claim 3, wherein the liquid container has a container outlet adapted to an inlet cross-section of the outlet nozzle. ### Claim 10 (depends on 3) The injection device according to claim 3, wherein the liquid container has an outlet side which is closed with a membrane or a pierceable plug which is pierceable by a hollow needle for opening the liquid container. ### Claim 11 (depends on 10) The injection device according to claim 10, wherein the hollow needle is provided on an inlet side of the outlet nozzle. ### Claim 12 (depends on 10) The injection device according to claim 10, wherein the hollow needle is formed in one piece with the outlet nozzle or forms the outlet nozzle itself. ### Claim 13 (depends on 3) The injection device according to claim 3, wherein the outlet nozzle is arranged or arrangeable integrally or replaceably on the liquid container. ### Claim 14 (depends on 3) The injection device according to claim 3, wherein the ejector device has an electromagnetically, chemically and/or gas operated drive. ### Claim 15 (depends on 3) The injection device according to claim 3, wherein the liquid container is replaceably accommodatable in the housing. ### Claim 16 An injection device for needleless injection of liquid into a substrate, in particular of a liquid, pharmaceutical or cosmetic product into a biological tissue, comprising a housing for accommodating a liquid container containing the liquid and an ejector device including a plunger for ejecting the liquid from the liquid container through an outlet nozzle, an acceleration device for continuously accelerating the plunger and the liquid container with the liquid contained therein in their entirety from a first position away from the outlet nozzle to an initial velocity inside the housing and a deceleration device adjacent the outlet nozzle for stopping the movement of the liquid container, wherein the acceleration device is configured to generate sufficient force that the liquid continues to move at a sufficient high velocity to eject a first partial quantity of liquid from the outlet nozzle into the substrate, with the plunger thereafter configured to travel towards the outlet nozzle at a lower velocity to eject a remaining second partial quantity of liquid from the container into the substrate; and wherein the liquid container has an outlet side which is closed with a membrane or a pierceable plug which is pierceable by a hollow needle for opening the liquid container. ### Claim 17 (depends on 16) The injection device according to claim 16, wherein the hollow needle is provided on an inlet side of the outlet nozzle. ### Claim 18 (depends on 16) The injection device according to claim 16, wherein the hollow needle is formed in one piece with the outlet nozzle or forms the outlet nozzle itself.