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US 12,226,535 B2Granted
Microneedle adhesive patch based on hydrogel formulation
AssigneePostech Academy-Industry Foundation
InventorsHyung Joon Cha, Eun Young Jeon, Jung Ho Lee, Geun Bae Lim
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Abstract
Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.
Claims10
A microneedle patch comprising:
- a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid;
- and
- a second hydrogel layer containing silk fibroin,
- wherein the mussel adhesive protein is crosslinked by covalent bonds, and
- wherein the weight ratio of the hyaluronic acid to the mussel adhesive protein ranges from 2:8 to 3:7.
2 more elements
Dependencies are inferred from the claim text.