Nasolacrimal drainage system implants for drug therapy
AssigneeMati Therapeutics Inc.
InventorsEugene de Juan, Jr., Stephen Boyd, Cary J. Reich, Alan R. Rapacki, Hanson S. Gifford, Mark Deem
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Abstract
An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
Claims14
A method for delivery of a therapeutic agent to an eye of a patient using a punctal plug, comprising:
- positioning the punctal plug into a lacrimal punctum of an eye wherein the punctal plug comprises a plug body and a drug insert, wherein the drug insert comprises a drug core comprising a therapeutic agent and a polymer matrix, and wherein the plug body comprises silicone;
- and,
- an impermeable sheath body partially covering the drug core, wherein the sheath body is configured to provide an exposed proximal end of the drug core in direct contact with tear fluid that releases the therapeutic agent to the eye;
- and,
- delivering a dose of the therapeutic agent to the eye for a sustained treatment period, wherein the punctal plug remains in position for the sustained treatment period for at least of one week to 3 months.
Dependencies are inferred from the claim text.