Polymeric core-shell particles
AssigneeBar-Ilan University
InventorsRachela Popovtzer, Chen Tzror-Azankot, Menachem Motiei
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Abstract
A nanoparticle having a lipidic core, wherein the nanoparticle is linked via first polymeric linkers to a glucose molecules, and is further linked via second polymeric linkers to chelating agents, and wherein a weight ratio of the chelating agents to the nanoparticle is 1:20 to 1:80, respectively, is disclosed. Uses of the nanoparticle, particularly for imaging a tumor in a mammal, are further disclosed.
Claims18
A nanoparticle having a lipid core comprising a plurality of lipids, wherein said lipid core is linked via a first polymeric linker to a 2-Deoxy-D-Glucose (2-DG) molecule and is further linked via a second polymeric linker to a chelating agent;
- wherein a portion of the lipids attached to said 2-DG-molecules from said plurality of lipids is between about 5 and 20 mol %;
- wherein a portion of the lipids attached to the chelating agent from said plurality of lipids is between 2.4 and about 10 mol %;
- and wherein a hydrodynamic diameter of said nanoparticle is between 60 and 200 nm;
- wherein the first and the second polymeric linkers comprise PEG;
- and wherein said chelating agent is a metal chelator selected from the group consisting of:
- 1-(1,3-carboxy-propyl)-4,7,10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTAGA), 1-(1,2-carboxyethyl)-4,7,10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTASA) or 1,4,7,10-tetraazaacyclo-dodecane-1,4,7,10-tetra-acetic acid (DOTA), or any combination thereof.
Dependencies are inferred from the claim text.