Foot-and-mouth disease virus-like particle antigen, and vaccine composition, preparation method, and application thereof

A type O foot-and-mouth disease virus-like particle vaccine, wherein the type O foot-and-mouth disease virus-like particle vaccine comprises a type O CATHAY topotype foot-and-mouth disease virus-like particle antigen and a pharmaceutically acceptable carrier that includes an adjuvant:

• wherein the type O foot-and-mouth disease virus-like particle antigen is a type O CATHAY topotype foot-and-mouth disease virus-like particle antigen, and the type O CATHAY topotype foot-and-mouth disease virus-like particle antigen is assembled by VP0, VP3 and VP1 antigen proteins of a type O CATHAY topotype foot-and-mouth disease virus (FMDV);
• wherein the VP0 antigen protein of the type O CATHAY topotype FMDV is encoded by SEQ ID NO:
• 1 or a degenerate sequence thereof;
• the VP3 antigen protein of the type O CATHAY topotype FMDV is encoded by SEQ ID NO:
• 2 or a degenerate sequence thereof;
• and the VP1 antigen protein of the type O CATHAY topotype FMDV is encoded by SEQ ID NO:
• 3 or a degenerate sequence thereof;
• wherein the type O foot-and-mouth disease virus-like particle vaccine further comprises an immunogenic amount of type O Southeast Asian (SEA) topotype foot-and-mouth disease virus-like particle antigen, and the type O SEA topotype foot-and-mouth disease virus-like particle antigen is assembled by VP4, VP2, VP3 and VP1 antigen proteins of type O SEA topotype FMDV;
• and
• wherein the VP4 antigen protein of type O SEA topotype FMDV is encoded by SEQ ID NO:
• 4 or a degenerate sequence thereof;
• the VP2 antigen protein of type O SEA topotype FMDV is encoded by SEQ ID NO:
• 5 or a degenerate sequence thereof;
• the VP3 antigen protein of type O SEA topotype FMDV is encoded by SEQ ID NO:
• 6 or a degenerate sequence thereof;
• and the VP1 antigen protein of type O SEA topotype FMDV is encoded by SEQ ID NO:
• 7 or a degenerate sequence thereof.