Eosinophils alleviate lung allograft rejection through their modulation of CD8+ t cells
AssigneeUniversity of Virginia Patent Foundation
InventorsAlexander Sasha Krupnick, Yizhan Guo, Oscar Okwudiri Onyema
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Abstract
Provided are methods for enhancing immunosuppression in the lung of a subject, In some embodiments, the methods include administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering is in an amount and via a route of administration sufficient to induce recruitment of eosinophils to the lung of the subject to thereby enhance immunosuppression in the lung of the subject. Also provided are methods for enhancing tolerance to lung transplants, enhancing recruitment of eosinophils to the lungs, modulating T cell-mediated immune responses in the lungs, and reducing TCR signal transduction in the lungs.
Claims15
A method for enhancing immunosuppression in the lung of a subject, the method comprising administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering is in an amount and via a route of administration sufficient to induce recruitment of eosinophils to the lung of the subject to thereby enhance immunosuppression in the lung of the subject, and further wherein the lung is a transplanted lung in the subject, the subject is an otherwise non-immunosuppressed subject, and the immunosuppression is sufficient to reduce rejection of the transplanted lung in the subject.
A method for enhancing tolerance to a lung transplant in a subject, the method comprising administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering is in an amount and via a route of administration sufficient to induce recruitment of eosinophils to the lung of the subject to thereby enhance tolerance to the lung transplant in the subject, wherein the subject is an otherwise non-immunosuppressed subject.
A method for enhancing recruitment of eosinophils to a lung of a subject, the method comprising administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering enhances recruitment of eosinophils to the lung of the subject, and further wherein the lung is a transplanted lung and where the subject is an otherwise non-immunosuppressed subject.
A method for modulating a T cell-mediated immune response in a lung of a subject, the method comprising administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering enhances recruitment of eosinophils to the lung of the subject to thereby modulate the T cell-mediated immune response in the lung of the subject, and further wherein the lung is a transplanted lung and where the subject is an otherwise non-immunosuppressed subject.
A method for reducing T cell antigen receptor (TCR) signal transduction in a lung of a subject, the method comprising administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering enhances recruitment of eosinophils to the lung of the subject to thereby reduce TCR signal transduction in the lung of the subject, and further wherein the lung is a transplanted lung and where the subject is an otherwise non-immunosuppressed subject.
Dependencies are inferred from the claim text.