Composition for preventing or treating neurodegenerative diseases, containing diterpene-based compound
AssigneeKorea Research Institute of Bioscience and Biotechnology
InventorsWon Gon Kim, Baek Soo Han, Jeong Su Byun, Van Minh Nguyen, Ha Young Choi
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Abstract
The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof. Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.
Claims5
A method of treating a neurodegenerative disease comprising administering a pharmaceutical composition consisting of a pharmaceutically effective amount of one and only one isolated diterpene selected from the group consisting of Formulas 1 to 10, or a pharmaceutically acceptable salt thereof as an active ingredient and a pharmaceutically acceptable carrier, optionally with conventional therapeutic agents for treating neurodegenerative diseases to a subject in need thereof, wherein the composition excludes an extract of Daphne genkwa:
Dependencies are inferred from the claim text.