# US 12,224,055 B2 · System and method for adaptive configuration of computerized cognitive training programs

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- Number: US 12,224,055 B2
- Document ID: US12224055B2
- Status: Granted
- Kind: B2
- Application number: 17/351,036
- Filed: 2021-06-17
- Published: 2022-12-22
- Granted: 2025-02-11
- Earliest claimed: 2021-06-17
- Assignees: Akili Interactive Labs, Inc.
- Applicants: Akili Interactive Labs, Inc.
- Inventors: Andrew C. Heusser
- Web page: https://patentgrep.com/patent/US12224055B2

## CPC

- G16H 20/70: relating to mental therapies, e.g. psychological therapy or autogenous training
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B 5/16: Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state}
- A61B 5/7475: {User input or interface means, e.g. keyboard, pointing device, joystick}
- G06F 3/0488: using a touch-screen or digitiser, e.g. input of commands through traced gestures
- G06N 5/04: Inference or reasoning models
- G09B 5/02: with visual presentation of the material to be studied, e.g. using film strip
- G09B 19/00: Teaching not covered by other main groups of this subclass (teaching or practice apparatus for gun-aiming or gun-laying F41G3/26)
- G16H 40/67: for remote operation
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16H 50/50: for simulation or modelling of medical disorders
- G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients
- A61B 5/4088: {Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia}
- A61B 5/7455: {characterised by tactile indication, e.g. vibration or electrical stimulation}
- G06F 3/0481: based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N)
- G06N: COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B)

## Abstract

A system, method, and computer platform product for an adaptive cognitive training platform. In accordance with various aspects of the present disclosure, an adaptive cognitive training platform is configured to process user activity data from one or more instances of a computerized cognitive training program to determine a baseline cognitive assessment for one or more cognitive abilities/skills of a user. The cognitive assessment model may be configured to further process the user activity data to predict a relative value or measure of efficacy for one or more computerized stimuli or interactions within the computerized cognitive training program. The adaptive cognitive training platform may be configured to configure, modify and/or present one or more graphical user interface elements for one or more subsequent instances of the computerized cognitive training program according to the predicted value or measure of efficacy of one or more cognitive training tasks.

## Claims

### Claim 1

A method for configuring a user interface within a computerized cognitive training regimen, comprising:
presenting, with a processor communicably engaged with a computing device, one or more instances of the computerized cognitive training regimen to a user, the computerized cognitive training regimen comprising two or more computerized cognitive training tasks presented via a display of the computing device, wherein a first task in the two or more computerized cognitive training tasks is configured to target a first cognitive ability of the user and a second task in the two or more computerized cognitive training tasks is configured to target a second cognitive ability of the user,
wherein the computerized cognitive training regimen comprises an interactive video game in which the two or more computerized cognitive training tasks are gameplay tasks associated with a gameplay progression of the interactive video game,
wherein each task in the two or more computerized cognitive training tasks comprises a set of computerized stimuli or interactions comprising dynamically rendered graphical elements rendered at a first graphical user interface screen of the interactive video game according to at least one response-deadline procedure;
receiving, with the processor via the computing device, a plurality of user input data in response to the two or more computerized cognitive training tasks,
wherein the plurality of user input data comprises a plurality of sensor data derived from an interaction of the user with a sensor device in response to the set of computerized stimuli or interactions;
processing, with the processor, the plurality of user input data according to a cognitive assessment model to determine a quantified measure of the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen;
analyzing, with the processor, the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen to determine at least one gameplay progression criterion for the interactive video game;
processing, with the processor, the plurality of user input data according to the cognitive assessment model to determine a predicted measure of efficacy for each task in the two or more computerized cognitive training tasks;
configuring, with the processor, a subsequent graphical user interface screen of the interactive video game according to the quantified measure of the first cognitive ability of the user and the second cognitive ability of the user and the at least one gameplay progression criterion,
wherein configuring the subsequent graphical user interface screen of the interactive video game comprises configuring or modifying a first set of computerized stimuli or interactions associated with a first task in the two or more computerized cognitive training tasks according to the predicted measure of efficacy,
wherein configuring or modifying the first set of computerized stimuli or interactions comprises dynamically modifying at least one graphical element in the first set of computerized stimuli or interactions,
wherein the at least one graphical element comprises a therapeutically active element configured to target the first cognitive ability of the user,
wherein the predicted measure of efficacy comprises a predicted incremental measure of improvement in the first cognitive ability of the user and/or the second cognitive ability of the user; and
presenting, with the processor via the display of the computing device, the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 2 (depends on 1)

The method of claim 1 further comprising determining, with the processor, a target measure of the first cognitive ability of the user and the second cognitive ability of the user according to the cognitive assessment model,
wherein the target measure comprises an estimated asymptotic maximum or estimated marginal output value for the predicted incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user.

### Claim 3 (depends on 1)

The method of claim 1 further comprising receiving, with the processor via the computing device, a subsequent plurality of user input data in response to presenting the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 4 (depends on 3)

The method of claim 3 further comprising estimating, with the processor, an incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user in response to presenting the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 5 (depends on 4)

The method of claim 4 further comprising processing, with the processor, the subsequent plurality of user input data according to the cognitive assessment model to determine an actual incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user.

### Claim 6 (depends on 5)

The method of claim 5 further comprising processing, with the processor, the subsequent plurality of user input data according to the cognitive assessment model to determine an updated predicted measure of efficacy for the computerized cognitive training regimen.

### Claim 7 (depends on 6)

The method of claim 6 further comprising configuring, with the processor, the subsequent graphical user interface screen of the interactive video game according to the updated predicted measure of efficacy.

### Claim 8 (depends on 1)

The method of claim 1 wherein the predicted measure of efficacy comprises calculating an argmax for each task in the two or more computerized cognitive training tasks according to the cognitive assessment model.

### Claim 9 (depends on 8)

The method of claim 8 further comprising configuring, with the processor, the subsequent graphical user interface screen of the interactive video game according to the calculated argmax.

### Claim 10

A system for configuring a user interface within a computerized cognitive training regimen, comprising:
a user interface device comprising a display and an input device comprising at least one sensor;
a processor communicably engaged with the user interface device; and
a non-transitory computer readable storage medium communicably engaged with the processor and encoded with processor-executable instructions that, when executed, cause the processor to perform one or more operations comprising:
presenting one or more instances of the computerized cognitive training regimen to a user, wherein each instance in the one or more instances comprises a graphical user interface configured to present two or more computerized cognitive training tasks via the display of the user interface device,
wherein a first task in the two or more computerized cognitive training tasks is configured to target a first cognitive ability of the user and a second task in the two or more computerized cognitive training tasks is configured to target a second cognitive ability of the user,
wherein the computerized cognitive training regimen comprises an interactive video game in which the two or more computerized cognitive training tasks are gameplay tasks associated with a gameplay progression of the interactive video game,
wherein each task in the two or more computerized cognitive training tasks comprises a set of computerized stimuli or interactions comprising dynamically rendered graphical elements rendered at a first graphical user interface screen of the interactive video game according to at least one response-deadline procedure;
receiving a plurality of user input data in response to the two or more computerized cognitive training tasks,
wherein the plurality of user input data comprises a plurality of sensor data derived from an interaction of the user with a sensor device in response to the set of computerized stimuli or interactions;
processing the plurality of user input data according to a cognitive assessment model to determine a quantified measure of the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen;
analyzing the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen to determine at least one gameplay progression criterion for the interactive video game;
processing the plurality of user input data according to the cognitive assessment model to determine a predicted measure of efficacy for each task in the two or more computerized cognitive training tasks;
configuring, with the processor, a subsequent graphical user interface screen of the interactive video game according to the quantified measure of the first cognitive ability of the user and the second cognitive ability of the user and the at least one gameplay progression criterion,
wherein configuring the subsequent graphical user interface screen of the interactive video game comprises configuring or modifying a first set of computerized stimuli or interactions associated with a first task in the two or more computerized cognitive training tasks according to the predicted measure of efficacy,
wherein configuring or modifying the first set of computerized stimuli or interactions comprises dynamically modifying at least one graphical element in the first set of computerized stimuli or interactions,
wherein the at least one graphical element comprises a therapeutically active element configured to target the first cognitive ability of the user,
wherein the predicted measure of efficacy comprises a predicted incremental measure of improvement in the first cognitive ability of the user and/or the second cognitive ability of the user; and
presenting, via the display of the user interface device, the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 11 (depends on 10)

The system of claim 10 wherein the one or more operations further comprise estimating an incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user in response to presenting the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 12 (depends on 11)

The system of claim 11 wherein the one or more operations further comprise determining a target measure of the first cognitive ability of the user and the second cognitive ability of the user according to the cognitive assessment model,
wherein the target measure comprises an asymptotic maximum or marginal output value for the incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user.

### Claim 13 (depends on 10)

The system of claim 10 wherein the one or more operations further comprise receiving a subsequent plurality of user input data in response to presenting the subsequent graphical user interface screen of the interactive video game to the user.

### Claim 14 (depends on 13)

The system of claim 13 wherein the one or more operations further comprise processing the subsequent plurality of user input data according to the cognitive assessment model to determine an actual incremental measure of improvement in the first cognitive ability of the user and the second cognitive ability of the user.

### Claim 15 (depends on 14)

The system of claim 14 wherein the one or more operations further comprise processing the subsequent plurality of user input data according to the cognitive assessment model to determine an updated predicted measure of efficacy for the two or more computerized cognitive training tasks.

### Claim 16 (depends on 15)

The system of claim 15 wherein the one or more operations further comprise configuring the subsequent graphical user interface screen of the interactive video game according to the updated predicted measure of efficacy.

### Claim 17 (depends on 10)

The system of claim 10 wherein the one or more operations further comprise calculating an argmax for each task in the two or more computerized cognitive training tasks according to the cognitive assessment model.

### Claim 18 (depends on 17)

The system of claim 17 wherein the one or more operations further comprise configuring the subsequent graphical user interface screen of the interactive video game according to the calculated argmax.

### Claim 19 (depends on 18)

The system of claim 18 wherein the one or more operations further comprise modifying or configuring one or more interface elements of the subsequent graphical user interface screen of the interactive video game according to the argmax,
wherein the one or more interface elements comprise at least one interface element for the two or more computerized cognitive training tasks.

### Claim 20

A non-transitory computer-readable medium encoded with instructions for commanding one or more processors to execute operations for configuring a user interface within a computerized cognitive training regimen, the operations comprising:
presenting one or more instances of the computerized cognitive training regimen to a user via a display of a computing device, wherein the computerized cognitive training regimen comprises an interactive video game comprising two or more computerized cognitive training tasks, wherein the two or more computerized cognitive training tasks are gameplay tasks associated with a gameplay progression of the interactive video game,
wherein a first task in the two or more computerized cognitive training tasks is configured to target a first cognitive ability of the user and a second task in the two or more computerized cognitive training tasks is configured to target a second cognitive ability of the user,
wherein each task in the two or more computerized cognitive training tasks comprises a set of computerized stimuli or interactions comprising dynamically rendered graphical elements rendered at a first graphical user interface screen of the interactive video game according to at least one response-deadline procedure;
receiving a plurality of user input data in response to the two or more computerized cognitive training tasks,
wherein the plurality of user input data comprises a plurality of sensor data derived from an interaction of the user with a sensor device in response to the set of computerized stimuli or interactions;
processing the plurality of user input data according to a cognitive assessment model to determine a quantified measure of the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen;
analyzing the first cognitive ability of the user and the second cognitive ability of the user for each instance in the one or more instances of the computerized cognitive training regimen to determine at least one gameplay progression criterion for the interactive video game;
processing the plurality of user input data according to the cognitive assessment model to determine a predicted measure of efficacy for each task in the two or more computerized cognitive training tasks;
configuring a subsequent graphical user interface screen of the interactive video game according to the quantified measure of the first cognitive ability of the user and the second cognitive ability of the user and the at least one gameplay progression criterion,
wherein configuring the subsequent graphical user interface screen of the interactive video game comprises configuring or modifying a first set of computerized stimuli or interactions associated with a first task in the two or more computerized cognitive training tasks according to the predicted measure of efficacy,
wherein configuring or modifying the first set of computerized stimuli or interactions comprises dynamically modifying at least one graphical element in the first set of computerized stimuli or interactions,
wherein the at least one graphical element comprises a therapeutically active element configured to target the first cognitive ability of the user,
wherein the predicted measure of efficacy comprises a predicted incremental measure of improvement in the first cognitive ability of the user and/or the second cognitive ability of the user; and
presenting the subsequent graphical user interface screen of the interactive video game to the user via the display of the computing device.