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US 12,222,354 B2Granted
Identification and quantitation of insulin-like growth factor-I variants by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsIevgen Motorykin, Nigel Clarke, Michael J. McPhaul, Zengru Wu
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Abstract
Methods are provided for detecting insulin-like growth factor-I (IGF-I) variant(s) in a sample. Methods provided herein are further directed to using the detected ion or ions to determine the presence of IGF1 variant(s) in the sample.
Claims7
A method for detecting insulin-like growth factor-I (IGF-I) in a sample, the method comprising:
- a. ionizing IGF-I in the sample to produce one or more ions detectable by mass spectrometry;
- b. detecting one or more of the ions comprising an ion with a mass-to-charge ratio selected from the group consisting of 1089.8±0.5, 1095±0.5, 1097.09±0.5, and 1098.09±0.5 by mass spectrometry;
- and
- c. using the detected ion or ions to determine the presence of IGF-I variant(s) in the sample.
1 more element
Dependencies are inferred from the claim text.