# US 12,222,304 B2 · Method and system for the analysis of biological material and use of such a system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,222,304 B2 - Document ID: US12222304B2 - Status: Granted - Kind: B2 - Application number: 17/231,601 - Filed: 2021-04-15 - Published: 2021-11-11 - Granted: 2025-02-11 - Earliest claimed: 2020-05-08 - Assignees: Netzsch-Gerätebau GmbH - Applicants: NETZSCH-Gerätebau GmbH - Inventors: Rebekka Taubmann - Web page: https://patentgrep.com/patent/US12222304B2 ## CPC - G01N 25/20: by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity (calorimeters per se G01K) - G01N 25/4866: {by using a differential method} - G01N 33/483: Physical analysis of biological material - G01N 33/48792: {Data management, e.g. communication with processing unit (for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C)} - G16H 10/40: for data related to laboratory analysis, e.g. patient specimen analysis - G16H 50/30: for calculating health indices; for individual health risk assessment - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A method for the analysis, in particular for analysis by dynamic difference calorimetry (DSC), of biological material, in particular blood, urine, sweat or skin tissue, with the steps of: introduction of a sample with a patient's biological material onto a sensor of a measuring device; acquisition of measured values by means of the measuring device; sending the measured values to an evaluation device, which communicates with the measuring device; assessment of the patient's state of health with the aid of data structures characterizing the state of health on the basis of the measured values by means of the evaluation device, on which a first application software instance is performed; and visualization or audio-visualization of the state of health on a display. The present invention further creates a system for the analysis of biological material and a use of such a system. ## Claims ### Claim 1 A system for analyzing biological material, the system comprising: a measuring device, which includes a sensor that contains a sample of a patient's biological material and which is designed to send measured values of the sample to an evaluation device; the evaluation device, which includes a first application software instance that is designed to receive the measured values and to assess the patient's state of health with the aid of data structures characterizing the state of health on the basis of the measured values, the evaluation device being designed to communicate with an external communication participant and receive datasets with medical information from the external communication participant for the assessment of the state of health; and a display, which is designed to visualize or audio-visualize the state of health; wherein the external communication participant includes a second application software instance, which is designed to send the datasets to the evaluation device and provide a more precise assessment of the state of health than the first application software instance of the evaluation device. ### Claim 2 (depends on 1) The system according to claim 1, wherein the measuring device is further designed to enable a thermal analysis process for measuring a released or absorbed amount of heat of the biological material during a thermal process. ### Claim 3 (depends on 1) The system according to claim 1, wherein the measuring device and/or the sensor are disposable products. ### Claim 4 (depends on 1) The system according to claim 1, wherein the measuring device, the evaluation device, and the display are at least partially surrounded by a housing. ### Claim 5 (depends on 1) The system according to claim 1, wherein the evaluation device comprises a communication interface, which is designed to establish a communication connection between the evaluation device and the external communication participant and to transmit the datasets with medical information from the external communication participant to the evaluation device. ### Claim 6 (depends on 5) The system according to claim 5, wherein the external communication participant is constituted as a mirror, a television, a server and/or computer hardware for the visualization or audio-visualization of the state of health. ### Claim 7 (depends on 1) A method of analyzing biological material, comprising: performing dynamic difference calorimetry of the biological material utilizing the system of claim 1; and detecting the patient's state of health based on the dynamic difference calorimetry. ### Claim 8 A system for analyzing biological material, the system comprising: a measuring device, which includes a sensor that contains a sample of a patient's biological material and which is designed to send measured values of the sample to an evaluation device; the evaluation device, which includes a first application software instance that is designed to receive the measured values and to assess the patient's state of health with the aid of data structures characterizing the state of health on the basis of the measured values; and a display, which is designed to visualize or audio-visualize the state of health; wherein the evaluation device also comprises a communication interface, which is designed to establish a communication connection between the evaluation device and an external communication participant and to transmit datasets with medical information from the external communication participant to the evaluation device for the assessment of the state of health; wherein the external communication participant is constituted as a data-processing device and is coupled communicatively with the evaluation device via the communication interface, wherein the medical information includes comparable measured values of other patients and/or treatment measures applied to comparable measured values of other patients. ### Claim 9 (depends on 8) The system according to claim 8, wherein the external communication participant is constituted as a mirror, a television, a server and/or computer hardware for the visualization or audio-visualization of the state of health. ### Claim 10 (depends on 8) The system according to claim 8, wherein the external communication participant or a server coupled via the communication interface includes a second application software instance, which is designed to send the datasets to the evaluation device and provide a more precise assessment of the state of health than the first application software instance of the evaluation device. ### Claim 11 (depends on 8) The system according to claim 8, wherein the measuring device is further designed to enable a thermal analysis process for measuring a released or absorbed amount of heat of the biological material during a thermal process. ### Claim 12 (depends on 8) The system according to claim 8, wherein the measuring device, the evaluation device, and the display are at least partially surrounded by a housing. ### Claim 13 A system for analyzing biological material, the system comprising: a measuring device, which includes a sensor that contains a sample of a patient's biological material and which is designed to send measured values of the sample to an evaluation device; the evaluation device, which includes a first application software instance that is designed to receive the measured values and to assess the patient's state of health with the aid of data structures characterizing the state of health on the basis of the measured values; and a display, which is designed to visualize or audio-visualize the state of health; wherein the evaluation device also comprises a communication interface, which is designed to establish a communication connection between the evaluation device and an external communication participant and to transmit datasets with medical information from the external communication participant to the evaluation device for the assessment of the state of health; wherein the external communication participant is constituted as a diagnostic device and/or as computer hardware, and is communicatively coupled with the evaluation device via the communication interface, wherein the medical information includes vital parameters of the patient. ### Claim 14 (depends on 13) The system according to claim 13, wherein the external communication participant is constituted as a mirror, a television, a server and/or computer hardware for the visualization or audio-visualization of the state of health. ### Claim 15 (depends on 13) The system according to claim 13, wherein the external communication participant or a server coupled via the communication interface includes a second application software instance, which is designed to send the datasets to the evaluation device and provide a more precise assessment of the state of health than the first application software instance of the evaluation device. ### Claim 16 (depends on 13) The system according to claim 13, wherein the measuring device is further designed to enable a thermal analysis process for measuring a released or absorbed amount of heat of the biological material during a thermal process. ### Claim 17 (depends on 13) The system according to claim 13, wherein the measuring device, the evaluation device, and the display are at least partially surrounded by a housing. ### Claim 18 (depends on 13) The system according to claim 13, wherein the vital parameters include at least one of blood sugar level, blood pressure, or heart rate; and wherein the diagnostic device is a blood sugar measuring device or blood pressure measuring device and/or the computer hardware is a fitness tracker.