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US 12,221,645 B2Granted
Processes for producing reduced coenzyme Q10
AssigneesKingdomway Biotechnology (Jiangsu) Co., Ltd., Inner Mongolia Kingdomway Pharmaceutical Co., Ltd., Jiangsu Chengxin Pharmaceutical Co., Ltd., Xiamen Kingdomway Group Company
InventorsJun Zhu, Bingrong Wang, Fei Xu, Fei Xing, Dan Li
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Abstract
Processes for producing reduced coenzyme Q10 (CoQ10) are provided. The processes may include preparing a reaction mixture, which includes oxidized CoQ10, a reductase, a supplement coenzyme, a coenzyme regeneration enzyme, and a substrate of the coenzyme regeneration enzyme, and providing a condition so that components of the reaction mixture react to produce the reduced CoQ10.
Claims11
A process for producing reduced coenzyme Q10 (CoQ10), comprising:
- preparing a reaction mixture, which includes oxidized CoQ10, a reductase, a supplement coenzyme, a coenzyme regeneration enzyme, and a substrate of the coenzyme regeneration enzyme, wherein the reductase comprises glutathione reductase (GR) derived from Ectothiorhodospira haloalkaliphil, and has the amino acid sequence of SEQ ID NO:
- 3, and the coenzyme regeneration enzyme comprises glucose dehydrogenase (GDH) derived from Bacillus subtilis, and has the amino acid sequence of SEQ ID NO:
- 4;
- and
- providing a condition so that components of the reaction mixture react to produce the reduced CoQ10.
2 more elements
Dependencies are inferred from the claim text.