US 12,221,475 B2Granted

Chimeric antigen receptor and application thereof

AssigneeCAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd.

InventorsWen Hu, Yongchao Yao, Wenzhong Guo, Yinbo Jiang, Shuozhou Huang, Ting Jiang, Jiaojiao Li, Zhu Tao, Yanli Gu, Huihui Zhang, Li Qin, Xiaoping Chen

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Abstract

Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.

Claims8

Dependent claims

A chimeric antigen receptor, wherein the chimeric antigen receptor contains an antigen recognition domain,

wherein the antigen recognition domain is a domain which recognizes a malarial protein VAR2CSA or a recombinant protein comprising any one or at least two placental-like chondroitin sulfate A-binding domains of the malarial protein VAR2CSA,
wherein the antigen recognition domain contains a variable heavy chain and a variable light chain,
wherein
the variable heavy chain comprises:
CDR1 having an amino acid sequence as shown in SEQ ID NO. 13;
CDR2 having an amino acid sequence as shown in SEQ ID NO. 14;
and
CDR3 having an amino acid sequence as shown in SEQ ID NO. 15;
and
the variable light chain comprises:
CDR1 having an amino acid sequence as shown in SEQ ID NO. 16;
CDR2 having an amino acid sequence as shown in SEQ ID NO. 17;
and
CDR3 having an amino acid sequence as shown in SEQ ID NO. 18.

11 more elements

Dependencies are inferred from the claim text.