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US 12,221,433 B2Granted
Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
AssigneeUnity Biotechnology, Inc.
InventorsAnne-Marie Beausoleil, Ryan Hudson
Life of this patent
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Abstract
The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Selected compounds in this class promote apoptosis in senescent cells, and are being developed for treating senescent-related conditions. Selected compounds in this class promote apoptosis in cancer cells, and can be developed as chemotherapeutic agents.
Claims1
A pharmaceutical composition comprising a compound:
- and one or more pharmaceutically acceptable excipients.
Dependencies are inferred from the claim text.