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US 12,221,413 B2Granted
Processes to produce brivaracetam
AssigneeSuzhou Pengxu Pharmatech Co., Ltd.
InventorsPeng Wang, Pixu Li, Qiang Wei, Yuanhua Liu
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Abstract
The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.
Claims9
A process for stereoselective preparation of brivaracetam XII comprising converting a compound of formula VII to brivaracetam XII:
- wherein R1 is H, saturated or unsaturated C1-20 alkyl or C1alkyl-unsubstituted or substituted aryl;
- and X is Cl, Br, I, OMs, or OTs;
- and wherein the converting comprises:
- reacting the compound of formula VII with(S)-2-aminobutanamide or its salt or alkyl(S)-2-aminobutanoate in a first solvent under basic conditions at a temperature in the range 25° C. to 200° C. to produce a compound of formula IX,
- isolating the compound of formula IX, and
- converting the isolated compound of formula IX to brivaracetam XII in a second solvent at a temperature in the range 25° C. to 200° C.
3 more elements
Dependencies are inferred from the claim text.