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US 12,220,665 B2Granted
Tangential flow filtration systems and methods
AssigneeRepligen Corporation
InventorsMichael Bransby, Derek Carroll, Philip Yuen, Ralf Kuriyel
Life of this patent
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Abstract
The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
Claims19
A method of harvesting a bioproduct, comprising:
- passing a cell culture media tangentially through at least one tubular depth filter (TDF) having a first end and a second end,
- wherein said passing the cell culture media comprises introducing a non-laminar fluid flow through the first end of the TDF by operating a system comprising the TDF at a filter flux above 400 Lm−2h−1 (LMH) and a shear rate of less than 16,000 s−1.
Dependencies are inferred from the claim text.