Highly loaded metal oxide materials by self-assembly for extended biologically active molecule release in medical and dental applications
AssigneeMesosil Inc.
InventorsCameron Alexander Stewart, Benjamin David Hatton, Yoav Finer
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Abstract
A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.
Claims3
A method of making a composite material comprising the steps of,
- forming particles by providing a mixture of an amphiphilic biologically active agent, a metal oxide precursor and a solvent, wherein the amphiphilic biologically active agent is present in an amount sufficient to self-assemble into a micellar system, and wherein the metal oxide condenses around the micellar system, and
- dispersing the particles comprising the biologically active agent in a resin,
- wherein the biologically active agent comprises octenidine or a salt thereof.
Dependencies are inferred from the claim text.