Complex comprising a cell penetrating peptide, a cargo and a TLR peptide agonist for treatment of colorectal cancer
AssigneeAmal Therapeutics SA
InventorsMadiha Derouazi, Elodie Belnoue
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Abstract
The present invention provides a novel complex for use in the prevention and/or treatment of colorectal cancer, the complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a)-c) are covalently linked. In particular, compositions for use in the prevention and/or treatment of colorectal cancer, such as a pharmaceutical compositions and vaccines are provided.
Claims26
A method for treating colorectal cancer or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof comprising administering to the subject a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one toll-like receptor (TLR) peptide agonist, wherein the at least one TLR peptide agonist is a TLR2 and/or TLR4 peptide agonist;
- and
- wherein the components a)—c) are covalently linked.
A method for treating colorectal cancer or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof comprising administering to the subject a vaccine comprising at least one of:
- (i) a complex comprising
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR2 peptide agonist and/or TLR4 peptide agonist;
- wherein the components a)—c) are covalently linked;
- (ii) a nucleic acid encoding the complex as defined (i);
- (iii) a vector comprising the nucleic acid as defined in (ii);
- (iv) a host cell comprising the vector as defined in (iii);
- or
- (v) a cell loaded with a complex as defined in (i).
A method for treating colorectal cancer or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising at least one complex comprising
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR2 peptide agonist and/or TLR4 peptide agonist;
- wherein the components a)—c) are covalently linked;
- and a pharmaceutically acceptable carrier.
A method for treating colorectal cancer or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof comprising administering to the subject a combination of
- (i) a complex comprising
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR2 peptide agonist and/or TLR4 peptide agonist;
- wherein the components a)—c) are covalently linked;
- and
- (ii) a chemotherapeutic agent, a targeted drug and/or an immunotherapeutic agent.
Dependencies are inferred from the claim text.