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US 12,220,432 B2Granted
Cardiac stem cells for cardiac repair
AssigneeUniversity of Maryland, Baltimore
InventorSunjay Kaushal
Life of this patent
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Abstract
Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
Claims9
A pharmaceutical composition comprising human, neonatal cardiac stem cells and a pharmaceutically acceptable carrier, wherein the human, neonatal cardiac stem cells:
- (a) are positive for protein expression of ckit, SDF-1α, VEGF-A, PDGF-B, IL-6, FGF-2, and Nkx2.5,
- (b) are negative for protein expression of ISL1;
- and
- (c) are negative for protein expression of CD31, CD106, CD140b, or CD86.
1 more element
Dependencies are inferred from the claim text.