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US 12,219,327 B2Granted
Substituted isoindolines as PI3K-alpha inhibitors
AssigneesRelay Therapeutics, Inc., D. E. Shaw Research, LLC
InventorsLucian V. Dipietro, Kelley C. Shortsleeves, Thomas H. Mclean, Alexandre Larivee, Fabrizio Giordanetto, André Lescarbeau, Alessandro Boezio, Hanmo Zhang
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Abstract
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.
Claims6
A compound, which is:
- or a pharmaceutically acceptable salt thereof.
A compound, which is:
- or a pharmaceutically acceptable salt thereof.
A compound, which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.