# US 12,217,424 B2 · Determining digital markers indicative of a neurological condition using eye movement parameters > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,217,424 B2 - Document ID: US12217424B2 - Status: Granted - Kind: B2 - Application number: 18/532,537 - Filed: 2023-12-07 - Published: 2024-04-11 - Granted: 2025-02-04 - Earliest claimed: 2021-05-03 - Assignees: NeuraLight Ltd. - Applicants: NeuraLight Ltd. - Inventors: Edmund Ben-Ami; Micha Yochanan Breakstone; Rotem Zvi Bar-Or; Vladimir Anisimov - Web page: https://patentgrep.com/patent/US12217424B2 ## CPC - A61B 5/163: {by tracking eye movement, gaze, or pupil change} - G06T 7/0012: {Biomedical image inspection} - A61B 3/0008: {provided with illuminating means (A61B3/117, A61B3/14 take precedence)} - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/005: {Constructional features of the display} - A61B 3/111: {for measuring interpupillary distance} - A61B 3/112: {for measuring diameter of pupils} - A61B 3/113: for determining or recording eye movement - A61B 5/0077: {Devices for viewing the surface of the body, e.g. camera, magnifying lens} - A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety} - A61B 5/7267: {involving training the classification device} - A61B 2576/02: specially adapted for a particular organ or body part - G06T 2207/10016: Video; Image sequence - G06T 2207/30041: Eye; Retina; Ophthalmic - G06V 40/18: Eye characteristics, e.g. of the iris - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G06V: IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING ## Abstract Disclosed are system, method, and computer program product embodiments for determining a digital marker. An embodiment operates by determining one or more oculometric parameters associated with an eye of a user using a video stream. The video stream comprises at least one image of a face of the user. The embodiment then determines a pupillary response function of brightness or a gaze response function by performing a deconvolution process based on at least the one or more oculometric parameters. The pupillary response function of brightness or the gaze response function is indicative of a response of the eye of the user to an external factor. The embodiment determines one or more digital markers of the user based on the pupillary response function of brightness or the gaze response function. The one or more digital markers are indicative of a neurological condition or a mental health condition of the user. ## Claims ### Claim 1 A computer-implemented method for efficiently determining a digital marker indicative of a neurological condition or a mental health condition, comprising: determining, using one or more processors, a one-dimensional direction of gaze based on one or more oculometric parameters associated with an eye of a user using a video stream, wherein the video stream comprises at least one image of a face of the user; determining, by performing a deconvolution of a time function of at least the one-dimensional direction of gaze, a gaze response function, wherein the gaze response function is indicative of a response of the eye of the user to an external factor; and determining one or more digital markers of the user based on the gaze response function, wherein the one or more digital markers are indicative of a neurological condition or a mental health condition of the user. ### Claim 2 (depends on 1) The computer-implemented method of claim 1, wherein the one or more oculometric parameters comprise one or more of an iris size, an iris translation, or an iris rotation; and wherein the method further comprises: determining the one-dimensional direction of gaze based on the one or more of the iris size, the iris translation, or the iris rotation. ### Claim 3 (depends on 2) The computer-implemented method of claim 2, further comprising: displaying a stimulus on a display of a user device while simultaneously capturing the at least one image of the face of the user, wherein the stimulus corresponds to the external factor; and wherein the determining the gaze response function comprises performing deconvolution on the one-dimensional direction of gaze and a target signal, wherein the target signal is based on the stimulus. ### Claim 4 (depends on 2) The computer-implemented method of claim 2, wherein the iris size, the iris translation, and the iris rotation are obtained using a maximum likelihood estimation technique. ### Claim 5 (depends on 1) The computer-implemented method of claim 1, wherein the one or more oculometric parameters are represented as a time series. ### Claim 6 (depends on 1) The computer-implemented method of claim 1, further comprising: displaying a stimulus on a display of a user device; and capturing the at least one image of the face of the user while simultaneously displaying the stimulus, wherein the stimulus comprises one of a moving target on the display or a change in an illumination of the display. ### Claim 7 (depends on 1) The computer-implemented method of claim 1, wherein the one-dimensional direction of gaze is a vertical direction of gaze. ### Claim 8 A system for efficiently determining a digital marker indicative of a neurological condition or a mental health condition, comprising: one or more memories; and at least one processor each coupled to at least one of the memories and configured to: determine a one-dimensional direction of gaze based on one or more oculometic parameters associated with an eye of a user using a video stream, wherein the video stream comprises at least one image of a face of the user; determine, by performing a deconvolution of a time function of at least the one-dimensional direction of gaze, a gaze response function, wherein the gaze response function is indicative of a response of the eye of the user to an external factor; and determine one or more digital markers of the user based on the gaze response function, wherein the one or more digital markers are indicative of a neurological condition or a mental health condition of the user. ### Claim 9 (depends on 8) The system of claim 8, wherein the one or more oculometric parameters comprise one or more of an iris size, an iris translation, or an iris rotation; and wherein the at least one processor is further configured to: determine the one-dimensional direction of gaze based on the one or more of the iris size, the iris translation, or the iris rotation. ### Claim 10 (depends on 9) The system of claim 9, wherein the at least one processor is further configured to: display a stimulus on a display of a user device simultaneously while capturing the at least one image, wherein the stimulus corresponds to the external factor; and wherein the determining the gaze response function comprises performing deconvolution on the one-dimensional direction of gaze and a target signal, wherein the target signal is based on the stimulus. ### Claim 11 (depends on 9) The system of claim 9, wherein the iris size, the iris translation, and the iris rotation are obtained using a maximum likelihood estimation technique. ### Claim 12 (depends on 8) The system of claim 8, wherein the one or more oculometric parameters are represented as a time series. ### Claim 13 (depends on 8) The system of claim 8, wherein the one-dimensional direction of gaze is a vertical direction of gaze. ### Claim 14 A non-transitory computer-readable medium having instructions stored thereon that, when executed by at least one computing device, cause the at least one computing device to perform operations comprising: determining a one-dimensional direction of gaze based on one or more oculometric parameters associated with an eye of a user using a video stream, wherein the video stream comprises at least one image of a face of the user; determining, by performing a deconvolution of a time function of at least the one-dimensional direction of gaze, a gaze response function, wherein gaze response function is indicative of a response of the eye of the user to an external factor; and determining one or more digital markers of the user based on the gaze response function, wherein the one or more digital markers are indicative of a neurological condition or a mental health condition of the user. ### Claim 15 (depends on 14) The non-transitory computer-readable medium of claim 14, wherein the one or more oculometric parameters comprise one or more of an iris size, an iris translation, or an iris rotation; and wherein the operations further comprise: determining the one-dimensional direction of gaze based on the one or more of the iris size, the iris translation, or the iris rotation. ### Claim 16 (depends on 15) The non-transitory computer-readable medium of claim 15, the operations further comprising: displaying a stimulus on a display of a user device while simultaneously capturing the at least one image, wherein the stimulus corresponds to the external factor; and wherein the determining the gaze response function comprises performing the deconvolution on the one-dimensional direction of gaze and a target signal, wherein the target signal is based on the stimulus. ### Claim 17 (depends on 15) The non-transitory computer-readable medium of claim 15, wherein the iris size, the iris translation, and the iris rotation are obtained using a maximum likelihood estimation technique. ### Claim 18 (depends on 14) The non-transitory computer-readable medium of claim 14, wherein the one or more oculometric parameters are represented as a time series. ### Claim 19 (depends on 14) The non-transitory computer-readable medium of claim 14, the operations further comprising: displaying a stimulus on a display of a user device; and capturing the at least one image of the face of the user while simultaneously displaying the stimulus, wherein the stimulus comprises one of a moving target on the display or a change in an illumination of the display. ### Claim 20 (depends on 14) The non-transitory computer-readable medium of claim 14, wherein the one-dimensional direction of gaze is a vertical direction of gaze.