# US 12,216,131 B2 · Apparatus having one or more sensors for sampling the headspace and process for sampling the headspace > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,216,131 B2 - Document ID: US12216131B2 - Status: Granted - Kind: B2 - Application number: 16/433,368 - Filed: 2019-06-06 - Published: 2019-12-12 - Granted: 2025-02-04 - Earliest claimed: 2018-06-08 - Assignees: Thermo Fisher Scientific Inc. - Applicants: Thermo Fisher Scientific SPA - Inventors: Tiziano Bosaglia; Riccardo Facchetti; Eugenio Pettenon; Flavio Antoniucci - Web page: https://patentgrep.com/patent/US12216131B2 ## CPC - G01N 30/12: by evaporation - G01N 35/00584: {Control arrangements for automatic analysers} - G01N 35/02: using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations {(G01N35/0098 and G01N35/0099 take precedence)} - G01N 35/025: {having a carousel or turntable for reaction cells or cuvettes} - G01N 30/16: Injection (G01N30/24 takes precedence) - G01N 30/24: Automatic injection systems - G01N 35/1095: {for supplying the samples to flow-through analysers (for a specific analyser see relevant groups, e.g. under G01N15/00, G01N21/00, G01N27/00, G01N30/00, H01J49/00)} - G01N 2001/2229: {Headspace sampling, i.e. vapour over liquid} - G01N 2035/00346: {Heating or cooling arrangements} - G01N 2035/0441: {for samples} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract The present invention relates to an apparatus (1) for sampling the headspace, comprising: a mobile station (2) provided with a plurality of housing seats (21) to house a plurality of containers (100) for sampling the headspace; an oven (3); a blocking device (4) comprising at least one first mobile element (41) that moves between a first position adapted to prevent a container (100) from passing from the mobile station (2) to the oven (3), and a second position adapted to allow a container (100) to pass from the mobile station (2) to the oven (3); at least one first sensor (5a) placed upstream of the first mobile element (41), to detect the presence of a container (100) in a housing seat (21); a movement element (6) moving between said mobile station (2) and the oven (3), the movement element being configured to move a container (100) from the mobile station (2) to the oven (3). ## Claims ### Claim 1 An apparatus for sampling a headspace of a container, comprising: a mobile station provided with a plurality of housing seats to house a plurality of containers for sampling the headspace of a container; a heater; a blocking device comprising at least one first mobile element that moves between at least two positions, a first position adapted to prevent a container from the plurality of containers from passing from said mobile station to said heater, and a second position adapted to allow a container from the plurality of containers to pass from said mobile station to said heater; at least one first sensor placed upstream of said at least one first mobile element, to detect a presence of a container from the plurality of containers in an operating position of said housing seats upstream of said heater; a movement element movable between said mobile station and said heater, the movement element being configured to move a container from the plurality of containers from said mobile station to said heater, and a second sensor placed downstream of said at least one first mobile element and outside the heater to detect the presence of a container from the plurality of containers in said heater, the movement element operable to move a container from the plurality of containers from the heater to a position near the second sensor to allow the second sensor to detect the presence of the container from the heater, and the apparatus configured to measure a length of time the container from the plurality of containers is detected by the at least one first sensor and the second sensor as the container is moved from said mobile station to said heater, and to determine a volume and a height of the container based on the measured length of time the container from the plurality of containers is detected by the at least one first sensor and the second sensor as the container is moved from said mobile station to said heater, wherein the mobile station is adapted to move the plurality of housing seats and the plurality of containers in a first direction, the movement element is adapted to move the containers from said mobile station to said heater along a second direction orthogonal to a plane containing the first direction, and the blocking device is adapted to prevent movement of the container along the second direction when in the first position. ### Claim 2 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein said at least one first mobile element is rotatable and an opening extending through said first mobile element is adapted to define said first and said second positions. ### Claim 3 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein said at least one first mobile element is movable to a third position adapted to prevent a container from the plurality of containers from passing from said mobile station to said heater and to allow contact between a container from the plurality of containers and said movement element. ### Claim 4 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein said blocking device further comprises a second mobile element disposed downstream of said at least one first mobile element, said second mobile element being movable between a first position adapted to prevent a container from the plurality of containers from passing from said mobile station to said heater, and a second position adapted to allow a container from the plurality of containers to pass from said mobile station to said heater. ### Claim 5 (depends on 4) The apparatus for sampling a headspace of a container according to claim 4, comprising said second sensor disposed downstream of said at least one first mobile element to detect the presence of a container from the plurality of containers in said heater wherein said second sensor placed downstream of said at least one first mobile element, is disposed upstream of said second mobile element. ### Claim 6 (depends on 1) A process for transferring a container from the plurality of containers from the mobile station to the heater of the apparatus according to claim 1 comprising the steps of: i) moving the mobile station so that a housing seat from said plurality of housing seats is arranged in a position; ii) operating the at least one first sensor to verify the presence of a container from the plurality of containers in the housing seat from said plurality of housing seats; iii) operating said movement element to reach said container from the plurality of containers; iv) moving said at least one first mobile element to the second position; v) operating said movement element so that said container from the plurality of containers is moved from said mobile station to said heater; wherein steps iv) and v) are carried out after the presence of the container from the plurality of containers in the housing seat from said plurality of housing seats has been confirmed in said step ii); wherein, in said step v), said volume and height of the container from the plurality of containers are determined, as a function of a signal of said first sensor and a signal of said second sensor that detect the presence of a container from the plurality of containers in said heater and measure a length of time the container from the plurality of containers is detected by the at least one first sensor and/or the second sensor as the container is moved from said mobile station to said heater. ### Claim 7 (depends on 6) The process for transferring the container according to claim 6 wherein, in said step iii), the at least one first mobile element is moved to a third position adapted to prevent a container from the plurality of containers from passing from said mobile station to said heater and to allow contact between a container from the plurality of containers and said movement element. ### Claim 8 (depends on 1) A process for transferring a container from the plurality of containers from the heater to the mobile station of the apparatus according to claim 1, which comprises the steps of: i′) moving the mobile station so that a housing seat is arranged in a position; ii′) operating the at least one first sensor to verify the absence of a container from the plurality of containers in said housing seat; iii′) operating said second sensor to verify a presence of a container from the plurality of containers in the heater; iv′) moving said at least one first mobile element to the second position; v′) operating said movement element so that said container from the plurality of containers is moved to said mobile station; vi′) moving said at least one first mobile element to the first position; wherein step iv′), v′) and vi′) are carried out after said step ii′), the absence of a container from the plurality of containers in the housing seat has been confirmed and if in said step iii′) the presence of a container from the plurality of containers in the heater has been confirmed. ### Claim 9 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein the heater has a duct configured to allow a container from said plurality of containers to be displaced between the mobile station and the heater. ### Claim 10 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein the movement element comprises an elevator configured to move a container from the plurality of containers from the mobile station to the heater. ### Claim 11 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein the at least one first mobile element has a solid portion and an opening, the opening having a first portion whose size is substantially equal to or larger than the section of a seat of said plurality of seats. ### Claim 12 (depends on 11) The apparatus for sampling a headspace of a container according to claim 11, wherein the opening of the at least one first mobile element has a second portion having at least one dimension smaller than the section of a housing seat from said plurality of housing seats, so that, when the second portion is placed at the housing seat provided with a container from the plurality of containers, said container cannot pass through the at least one first mobile element. ### Claim 13 (depends on 1) The apparatus according to claim 1, wherein the second sensor is configured to check the presence of a container in the heater, via movement of the movement element so as to arrange the container near the second sensor. ### Claim 14 (depends on 13) The apparatus according to claim 13, wherein the movement element comprises an elevator lifted by such a height that the container does not enter the seat but is anyway arranged near the second sensor. ### Claim 15 (depends on 6) The process according to claim 6, wherein the second sensor is configured to check the presence of a container in the heater, via movement of the movement element so as to arrange the container near the second sensor, and the movement element comprises an elevator lifted by such a height that the container does not enter the seat but is anyway arranged near the second sensor. ### Claim 16 (depends on 1) The apparatus for sampling a headspace of a container according to claim 1, wherein the mobile station is adapted to rotate the housing seats along the plane and the at least one first sensor and the second sensor are adapted to detect a position of the container along said second direction. ### Claim 17 (depends on 6) The process as in claim 6, wherein the at least one first sensor and the second sensor are in fixed position along the second direction and wherein, in said step v), the volume and/or height of the container is estimated based on the length of time and a speed of the movement element. ### Claim 18 (depends on 1) The apparatus according to claim 1, wherein the apparatus is configured to determine a correct depth to which an element suitable for collecting a sample has to be inserted into a container of the plurality of containers, and to determine a correct amount of gas to be inserted into the container based on the measured volume and height of the container. ### Claim 19 (depends on 6) The process according to claim 6, further comprising the steps of vi) determining a correct depth to which an element suitable for collecting a sample has to be inserted into the container from the plurality of containers, based on the measured volume and height of the container; and vii) inserting said element into said container to said correct depth. ### Claim 20 An apparatus for sampling a headspace of a container, comprising: a mobile station provided with a plurality of housing seats to house a plurality of containers for sampling the headspace of a container; a heater; a blocking device comprising at least one first mobile element that moves between at least two positions, a first position adapted to prevent a container from the plurality of containers from passing from said mobile station to said heater, and a second position adapted to allow a container from the plurality of containers to pass from said mobile station to said heater; at least one first sensor placed upstream of said at least one first mobile element, to detect a presence of a container from the plurality of containers in an operating position of said housing seats upstream of said heater; a movement element movable between said mobile station and said heater, the movement element being configured to move a container from the plurality of containers from said mobile station to said heater, and a second sensor placed downstream of said at least one first mobile element and outside the heater to detect the presence of a container from the plurality of containers in said heater, the movement element operable to move a container from the plurality of containers from the heater to a position near the second sensor to allow the second sensor to detect the presence of the container from the heater, and the apparatus being configured to estimate measure a length of time the container from the plurality of containers is detected by the at least one first sensor and the second sensor as the container is moved from said mobile station to said heater, and to determine a volume and a height of the container based on the measured length of time the container from the plurality of containers is detected by the at least one first sensor and the second sensor as the container is moved from said mobile station to said heater, wherein the mobile station is adapted to move the plurality of housing seats and the plurality of containers in a first direction, the movement element is adapted to move the containers from said mobile station to said heater along a second direction orthogonal to a plane containing the first direction, and the blocking device is adapted to prevent movement of the container along the second direction when in the first position, wherein the at least one first sensor and the second sensor are in fixed position along the second direction and the height of the container is estimated based on speed of the movement element and an amount of time the container is detected by the sensors. ### Claim 21 (depends on 20) The apparatus according to claim 20, wherein the apparatus is configured to determine a correct depth to which an element suitable for collecting a sample has to be inserted into a container of the plurality of containers, and to determine a correct amount of gas to be inserted into the container based on the measured volume and height of the container.