# US 12,216,036 B2 · Particle size distribution measuring apparatus and particle size distribution measuring method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,216,036 B2 - Document ID: US12216036B2 - Status: Granted - Kind: B2 - Application number: 17/756,097 - Filed: 2020-11-09 - Published: 2022-12-22 - Granted: 2025-02-04 - Earliest claimed: 2019-11-19 - Assignees: Horiba, Ltd. - Applicants: HORIBA, Ltd. - Inventors: Tetsuji Yamaguchi; Tetsuya Mori; Makoto Nagura - Web page: https://patentgrep.com/patent/US12216036B2 ## CPC - G01N 15/0205: by optical means - G01N 15/0211: {Investigating a scatter or diffraction pattern} - G01N 21/01: Arrangements or apparatus for facilitating the optical investigation - G01N 21/49: within a body or fluid - G01N 2021/1704: {in gases} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A particle size distribution measuring apparatus includes a light source that emits measurement light to a sample accommodated in a cell including a pair of light transmission plates separated from each other, one or a plurality of detectors that detects the measurement light scattered in the sample, and a particle size distribution calculator that calculates a particle size distribution of a particle group included in the sample based on output signals of the detectors. The particle size distribution measuring apparatus further includes a force applying mechanism that moves at least one of the light transmission plates to apply pressure or a shearing force to the sample in the cell, in which the particle size distribution calculator is configured to calculate the particle size distribution at the time when the pressure or the shearing force applied to the sample has changed from a first state to a second state. ## Claims ### Claim 1 A particle size distribution measuring apparatus comprising: a light source that emits measurement light to a sample accommodated in a cell including a pair of light transmission plates separated from each other by a predetermined distance; one or a plurality of detectors that detects the measurement light scattered in the sample; and a particle size distribution calculator that calculates a particle size distribution of a particle group included in the sample based on output signals of the detectors, the particle size distribution measuring apparatus further comprising: a force applying mechanism that moves at least one of the pair of light transmission plates to change a pressure or a shearing force applied to the sample in the cell, wherein the particle size distribution calculator is configured to calculate the particle size distribution at a time point when the pressure or the shearing force applied to the sample has changed from a first state to a second state. ### Claim 2 (depends on 1) The particle size distribution measuring apparatus according to claim 1, wherein the force applying mechanism is configured to bring the pair of light transmission plates close to each other to change the pressure applied to the sample in the cell, or to rotate one of the pair of light transmission plates with respect to an other of the pair of light transmission plates to change the shearing force applied to the sample in the cell. ### Claim 3 (depends on 1) The particle size distribution measuring apparatus according to claim 1, further comprising: a pressure feeding part that pressure-feeds the sample into the cell and changes the pressure of the sample in the cell. ### Claim 4 (depends on 1) The particle size distribution measuring apparatus according to claim 1, further comprising: an electromagnetic field applying mechanism that applies at least one of an electric field and a magnetic field to the sample, wherein the particle size distribution calculator is configured to calculate the particle size distribution at each time point in a state in which the electric field or the magnetic field is being applied to the sample. ### Claim 5 (depends on 1) The particle size distribution measuring apparatus according to claim 1, further comprising: an ultrasonic wave applying mechanism that applies an ultrasonic wave to the sample, wherein the particle size distribution calculator is configured to calculate the particle size distribution at each time point in a state in which the ultrasonic wave is being applied to the sample. ### Claim 6 (depends on 1) The particle size distribution measuring apparatus according to claim 1, further comprising: a working light irradiator that irradiates inside the cell with working light that changes a state of the sample by photoreaction, wherein the particle size distribution calculator is configured to calculate the particle size distribution at each time point in a state in which the sample is being irradiated with the working light. ### Claim 7 (depends on 1) The particle size distribution measuring apparatus according to claim 1, wherein the light source emits the measurement light in a direction that is directed upward, the sample is arranged above the light source, and the one or plurality of the detectors is arranged at a position where the measurement light scattered by the sample can be detected. ### Claim 8 (depends on 7) The particle size distribution measuring apparatus according to claim 7, further comprising: a measurement chamber in which a sample stage and the one or plurality of the detectors is accommodated and an inside is maintained at a predetermined pressure or degree of vacuum; and an introduction mechanism that introduces gas containing a powder sample into the measurement chamber from an outside of the measurement chamber by a pressure difference between the inside and the outside of the measurement chamber. ### Claim 9 (depends on 8) The particle size distribution measuring apparatus according to claim 8, wherein the inside of the measurement chamber is brought into a nitrogen atmosphere. ### Claim 10 (depends on 8) The particle size distribution measuring apparatus according to claim 8, wherein the sample stage is configured to be usable at least for observation with a microscope. ### Claim 11 A particle size distribution measuring method that uses a particle size distribution measuring apparatus including a light source that emits measurement light to a sample accommodated in a cell including a pair of light transmission plates separated from each other by a predetermined distance, one or a plurality of detectors that detects the measurement light scattered in the sample, and a particle size distribution calculator that calculates a particle size distribution of a particle group included in the sample based on output signals of the detectors, the method comprising moving at least one of the pair of light transmission plates to change a pressure or a shearing force applied to the sample in the cell and calculating the particle size distribution at a time point when pressure or a shearing force applied to the sample in the cell has changed from a first state to a second state.