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US 12,215,341 B2Granted
Hybrid immolative cell-penetrating complexes for nucleic acid delivery
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsTim R. Blake, Robert M. Waymouth, Paul Wender, Ronald Levy, Ole Audun Werner Haabeth, Matthew Frank, Adrienne Sallets
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Abstract
There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
Claims15
A cationic amphipathic polymer of the formula:
- wherein
- R1A and R2A are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R201 is oleyl;
- R202 is nonenyl;
- n21 is 1 to 100;
- n22 is 1 to 100;
- and
- n is 2to 50.
5 more elements
Dependencies are inferred from the claim text.