Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
AssigneeIconic Therapeutics LLC
InventorsJan-Willem Theunissen, Andrew D. Avery, Allen G. Cai, Anthony Byron Cooper, Thi-Sau Migone
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Abstract
Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs. Also provided herein are methods of making and using the antibodies or ADCs, such as therapeutic and diagnostic methods.
Claims11
An antibody which binds to the extracellular domain of human Tissue Factor (TF), wherein the antibody comprises a VH-CDR1, a VH-CDR2, and a VH-CDR3 comprising the amino acid sequences of the VH-CDR1, the VH-CDR2, and the VH-CDR3, respectively, as set forth in a VH comprising the amino acid sequence of SEQ ID NO:
- 151, and a VL-CDR1, a VL-CDR2, and a VL-CDR3 comprising the amino acid sequences of the VL-CDR1, the VL-CDR2, and the VL-CDR3, respectively, as set forth in a VL comprising the amino acid sequence of SEQ ID NO:
- 152.
Dependencies are inferred from the claim text.