# US 12,215,125 B2 · Method for spray drying D-tagatose > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,215,125 B2 - Document ID: US12215125B2 - Status: Granted - Kind: B2 - Application number: 18/244,136 - Filed: 2023-09-08 - Published: 2024-01-04 - Granted: 2025-02-04 - Earliest claimed: 2020-09-21 - Assignees: University of Kentucky Research Foundation - Applicants: University of Kentucky Research Foundation - Inventors: Heather R. Campbell - Web page: https://patentgrep.com/patent/US12215125B2 ## CPC - A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21) - C07H 3/02: Monosaccharides - C13K 13/00: Sugars not otherwise provided for in this class - A61K 9/1623: {Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules} - A61K 9/1635: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates} - A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)} - A61K 9/1694: {resulting in granules or microspheres of the matrix type containing more than 5% of excipient} - B01J 2/04: in a gaseous medium {(if combined with suspending the material in a gas, e.g. fluidised beds B01J2/16)} - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13) - C13K: SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES (chemically synthesised sugars or sugar derivatives C07H; polysaccharides, e.g. starch, derivatives thereof C08B; malt C12C; fermentation or enzyme-using processes for preparing compounds containing saccharide radicals C12P19/00; production of sucrose C13B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS ## Abstract A D-tagatose spray-drying feed formulation is a mixture of D-tagatose and a functional excipient co-dissolved in a solvent to produce a excipient/D-tagatose composite having a glass transition temperature of greater than 30° C. A method of spray-drying D-tagatose includes the steps of (a) preparing the D-tagatose spray-drying formulation, (b) atomizing the D-tagatose spray-drying formulation in a drying chamber containing a hot inert processing gas and evaporating droplets to produce solid particles of excipient/D-tagatose composite and (c) separating and collecting the solid particles of excipient/D-tagatose composite from the processing gas. ## Claims ### Claim 1 A method of spray-drying D-tagatose, comprising: preparing a D-tagatose spray-drying feed formulation consisting of a mixture of D-tagatose and a functional polymer excipient co-dissolved in a solvent to produce a functional polymer excipient/D-tagatose composite having a glass transition temperature of greater than 30° C.; atomizing the D-tagatose spray-drying formulation in a drying chamber containing an inert processing gas and evaporating droplets to produce solid particles of D-tagatose; and separating and collecting the solid particles of the functional polymer excipient/D-tagatose composite from the processing gas. ### Claim 2 (depends on 1) The method of claim 1, wherein the solvent includes water and acetone, water and methanol, water and propanol, or water and ethanol. ### Claim 3 (depends on 2) The method of claim 2, wherein using an amorphous polymer, a sugar that has an amorphous state, hydroxypropylmethylcellulose acetate succinate, polyvinylpyrrolidone, D-trehalose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, citric acid or combinations thereof is used as the functional polymer excipient. ### Claim 4 (depends on 3) The method of claim 3, wherein the D-tagatose and the functional polymer excipient are mixed at a weight ratio of about 1:1. ### Claim 5 (depends on 4) The method of claim 4, wherein the acetone and the water are provided at a volume ratio of between 1:1 and 4.6:1. ### Claim 6 A method of spray-drying D-tagatose, comprising: spraying a mixture consisting of D-tagatose and a functional polymer excipient co-dissolved in a solvent to produce a functional polymer excipient/D-tagatose composite having a glass transition temperature of greater than 30° C. into a drying chamber containing an inert processing gas; and collecting spray-dried particles of the functional polymer excipient/D-tagatose composite. ### Claim 7 (depends on 6) The method of claim 6, wherein the solvent includes water and acetone, water and methanol, water and propanol, or water and ethanol. ### Claim 8 (depends on 7) The method of claim 7, wherein an amorphous polymer, a sugar that has an amorphous state, hydroxypropylmethylcellulose acetate succinate, polyvinylpyrrolidone, D-trehalose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, citric acid or combinations thereof is used as the functional polymer excipient. ### Claim 9 (depends on 8) The method of claim 8, including mixing the D-tagatose and the functional polymer excipient at a weight ratio of about 1:1. ### Claim 10 (depends on 9) The method of claim 9, including providing the acetone and the water are provided at a volume ratio of between 1:1 and 4.6:1.