# US 12,215,111 B2 · Imidazopyridazine IL-17 inhibitor compounds

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- Number: US 12,215,111 B2
- Document ID: US12215111B2
- Status: Granted
- Kind: B2
- Application number: 17/935,329
- Filed: 2022-09-26
- Published: 2023-05-11
- Granted: 2025-02-04
- Earliest claimed: 2021-09-27
- Assignees: Janssen Pharmaceutica NV
- Applicants: Janssen Pharmaceutica NV
- Inventors: Steven D. Goldberg; Douglas C. Behenna; Deane Gordon; Luke E. Hanna; Steven A. Loskot; Stefan McCarver; Steven P. Meduna; Brock T. Shireman; Alexander E. Valdes; Jennifer D. Venable; Dongpei Wu
- Web page: https://patentgrep.com/patent/US12215111B2

## CPC

- C07D 487/04: Ortho-condensed systems
- A61P 17/06: Antipsoriatics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

## Claims

### Claim 1

A compound or a pharmaceutically acceptable salt thereof, having a formula selected from the group consisting of:

### Claim 2

A compound or a pharmaceutically acceptable salt thereof, having a formula selected from the group consisting of:

### Claim 3

A compound or a pharmaceutically acceptable salt thereof, having a formula selected from the group consisting of:

### Claim 4 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 5 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 6 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 7 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 8 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 9 (depends on 2)

The compound of claim 2 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 10 (depends on 2)

The compound of claim 2 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 11 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 12 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 13 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 14 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 15 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 16 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 17 (depends on 3)

The compound of claim 3 or a pharmaceutically acceptable salt thereof, having the following structure:

### Claim 18 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 19 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 20 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 21 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 22 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 23 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula:

### Claim 24 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, having the following formula: