Microfluidic systems for multiple bioreactors and applications of same

A fluidic device, comprising:

• a fluidic chip having a body and a fluidic network formed in the body, the fluidic network comprising a plurality of fluidic channels in fluidic communication with a plurality of input ports, at least one output port, and at least one sensing port;
• and
• an actuator configured to engage with the fluidic network to control each fluidic channel to switch between an open state in which fluidic flow through said fluidic channel is permitted and a closed state in which no fluidic flow through said fluidic channel is permitted, so as to selectively collect fluid from multiple inputs via the plurality of input ports, and direct either all of the multiple inputs to the at least one output port, or all but a single selected input to the at least one output port and the single selected input to the at least one sensing port to which an analytical instrument is operably connected,
• wherein the plurality of input ports is operably coupled with a plurality of fluidic modules, wherein in operation, the plurality of fluidic modules is individually perfused, and outputs of all of the plurality of fluidic modules are directed to the at least one output port, or an output of any one of the plurality of fluidic modules is directed to the at least one sensing port, while outputs of all other fluidic modules of the plurality of fluidic modules are directed to the at least one output port,
• wherein the plurality of fluidic channels comprises a first common channel, a second common channel, and a plurality of intermediate channels, each intermediate channel being in fluidic communication with at least one of the plurality of input ports and connected to the first common channel and/or the second common channel, and
• wherein the actuator comprises
• a plurality of actuating elements disposed on the body of the fluidic chip with each actuating element at a location that is over an intermediate channel and is located between a respective port and one of the first common channel and the second common channel to which said intermediate channel is connected, wherein the plurality of actuating elements comprises caged actuating elements;
• and
• an actuator head having a cylinder shape configured to be rotatable over the plurality of actuating elements, and including one or more grooves, one or more reliefs, and/or one or more pockets operably engaging with the plurality of actuating elements for selectively compressing or relaxing each of the plurality of actuating elements, such that compression of said actuating element on the body causes fluidic flow between said respective port and said one of the first common channel and the second common channel through said intermediate channel to be occluded so that said intermediate channel is in the closed state, or relaxation of said actuating element on the body causes fluidic flow between said respective port and said one of the first common channel and the second common channel through said intermediate channel to flow so that said intermediate channel is in the open state;
• and
• wherein the fluidic chip has a circular shape adapted for engaging with the cylinder shaped actuator head.