# US 12,214,196 B2 · Systems and methods for treatment of cancer using alternating electric field generation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,214,196 B2 - Document ID: US12214196B2 - Status: Granted - Kind: B2 - Application number: 18/155,849 - Filed: 2023-01-18 - Published: 2023-05-18 - Granted: 2025-02-04 - Earliest claimed: 2018-07-17 - Assignees: Dignity Health - Applicants: Dignity Health - Inventors: Benjamin Hendricks; Kris Smith - Web page: https://patentgrep.com/patent/US12214196B2 ## CPC - A61N 1/3606: {adapted for a particular treatment} - A61N 1/0531: {Brain cortex electrodes} - A61N 1/0534: {Electrodes for deep brain stimulation} - A61N 1/36002: {Cancer treatment, e.g. tumour} - A61N 1/36139: {with automatic adjustment} - A61N 1/36146: {specified by the stimulation parameters} - A61N 1/37211: {Means for communicating with stimulators} - A61N 1/37235: {Aspects of the external programmer} - A61N 1/40: Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} - A61N 1/37514: {Brain implants} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein. ## Claims ### Claim 1 A system for the treatment of brain cancer, comprising: an alternating electric field generation apparatus, comprising: an electrode array, comprising: a plurality of subdural electrodes, wherein each of the subdural electrodes is implantable subdurally onto the brain of a patient; a plurality of deep-stimulating electrodes, wherein each of the plurality of deep-stimulating electrodes is implantable within the brain of the patient; wherein the electrode array delivers an alternating electric field to the tissue of the brain through the plurality of subdural electrodes and the plurality of deep-stimulating electrodes; and a processor in communication with a waveform generator and a memory, the waveform generator being in operative communication with the electrode array and the memory including instructions which, when executed, cause the processor to: apply, by the waveform generator and at the electrode array, a waveform representative of the alternating electric field and configured for the treatment of brain cancer; receive feedback from the electrode array following application of the waveform at the electrode array; and determine a set of parameters of the waveform applied by the waveform generator and at the electrode array based on the feedback received from the electrode array. ### Claim 2 (depends on 1) The system of claim 1, further comprising a wireless module, wherein the wireless module is operable to communicate with the external computer wirelessly. ### Claim 3 (depends on 2) The system of claim 2, wherein the processor is operable to receive data pertaining to electric field strength from the electrode array, wherein the processing unit is in operative communication with the wireless module. ### Claim 4 (depends on 1) The system of claim 1, further comprising: a plurality of conductive wires, wherein one or more of the plurality of conductive wires are operable to transmit data pertaining to electric field strength from the electrode array to the controller module, and wherein one or more of the plurality of conductive wires are operable to transmit the waveform from the waveform generator to the electrode array. ### Claim 5 (depends on 1) The system of claim 1, wherein the processor is operable to incorporate the feedback from the electrode array, a location of each of the plurality of subdural electrodes on the brain, and a location of each of the plurality of deep stimulating electrodes within the brain. ### Claim 6 (depends on 5) The system of claim 5, wherein the processor is operable to simulate effects of the set of parameters pertaining to the waveform on the brain, wherein the waveform is representative of the alternating electric field. ### Claim 7 An alternating electric field generation apparatus for the treatment of brain cancer, comprising: an electrode array, comprising a plurality of electrodes, wherein each of the plurality of electrodes is implantable onto or within a brain and wherein the electrode array delivers an alternating electric field to tissue of the brain; and a controller module in operative communication with the electrode array, the controller module comprising: a waveform generator, wherein the waveform generator is operable to generate a waveform representative of the alternating electric field and configured for the treatment of brain cancer, wherein the waveform is transmitted to the electrode array; and a processing unit, wherein the processing unit is operable to communicate a set of waveform parameters to the waveform generator; and wherein the waveform generator is operable to transmit a waveform to the electrode array by one or more wires; wherein the processor is operable to receive a set of measured aspects of the alternating electric field from one or more of the plurality of electrodes of the electrode array; wherein one or more of a plurality of conductive wires are operable to transmit the set of measured aspects of the alternating electric field from the electrode array to the controller module. ### Claim 8 (depends on 7) The apparatus of claim 7, comprising a plurality of conductive wires, wherein one or more of the plurality of conductive wires are operable to transmit the waveform from the controller module to the electrode array. ### Claim 9 (depends on 7) The apparatus of claim 7, wherein the plurality of electrodes include one or more deep stimulating electrodes defining a rod-shaped member and having one or more conductive contacts disposed along the rod-shaped member, wherein a proximal end of each of the plurality of deep stimulating members is in operative association with one or more of the plurality of conductive wires. ### Claim 10 (depends on 7) The apparatus of claim 7, wherein the plurality of electrodes include one or more subdural electrodes having opposing faces, wherein a distal face of the opposing faces comprises a conductive contact and wherein a proximal face of the opposing faces is in operative association with one or more conductive wires. ### Claim 11 A method for the treatment of cancer using an alternating electric field generation system, the method comprising: delivering an alternating electric field configured for treatment of brain cancer to a brain at a plurality electrodes of an alternating electric field generation system, wherein one or more of the plurality of electrodes are operable to measure aspects of the alternating electric field and communicate aspects of the alternating electric field to a controller module of the alternating electric field generation system; and optimizing a set of waveform parameters of the alternating electric field generation system using the measured aspects of the alternating electric field and a set of locations representative of each electrode of the plurality of electrodes. ### Claim 12 (depends on 11) The method of claim 11, wherein the optimization of the alternating electric field generation system is performed by an external computer, wherein the external computer computes the set of waveform parameters for the alternating electric field generation system using a simulation environment application. ### Claim 13 (depends on 12) The method of claim 12, wherein the controller module is operable to send the measured aspects of the alternating electric field to the external computer, and wherein the external computer is operable to send the set of waveform parameters to the controller module. ### Claim 14 (depends on 11) The method of claim 11, further comprising: determining an optimal placement configuration for each of the plurality of electrodes using cranial mapping software. ### Claim 15 (depends on 11) The method of claim 11, further comprising: initializing the alternating electric field generation system, wherein a set of initial waveform parameters are sent to the controller module. ### Claim 16 (depends on 12) The method of claim 12, wherein the simulation environment application predicts changes in the alternating electric field corresponding to a change in a waveform transmitted to the plurality of subdural electrodes or deep-stimulating electrodes. ### Claim 17 (depends on 16) The method of claim 16, wherein the simulation environment application is operable to obtain a set of locations for each of the plurality of electrodes and calculate a predicted distribution of the alternating electric field based on the waveform delivered to each of the plurality of electrodes. ### Claim 18 (depends on 17) The method of claim 17, wherein the alternating electric field generation system is optimized by choosing the set of optimal waveform parameters which deliver an alternating electric field of appropriate distribution and strength to a cancerous region of the brain, wherein the set of optimal waveform parameters is representative of the waveform delivered to each of the plurality of electrodes. ### Claim 19 (depends on 11) The method of claim 11, further comprising transmitting the set of waveform parameters to the controller module for application at the plurality of electrodes. ### Claim 20 (depends on 11) The method of claim 11, further comprising implanting the plurality of electrodes of the alternating electric field generation system within the brain.