# US 12,214,172 B2 · Auto-injector > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,214,172 B2 - Document ID: US12214172B2 - Status: Granted - Kind: B2 - Application number: 18/755,897 - Filed: 2024-06-27 - Published: 2024-10-24 - Granted: 2025-02-04 - Earliest claimed: 2011-02-18 - Assignees: Sanofi-Aventis Deutschland GmbH - Applicants: Sanofi-Aventis Deutschland GMBH - Inventors: Simon Francis Brereton; Thomas Kemp; Rosie Burnell; Matthew Ekman - Web page: https://patentgrep.com/patent/US12214172B2 ## CPC - A61M 5/31501: {Means for blocking or restricting the movement of the rod or piston (A61M5/5013 takes precedence)} - A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence) - A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)} - A61M 5/3157: {Means providing feedback signals when administration is completed (A61M5/20 takes precedence)} - A61M 5/3158: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button} - A61M 5/322: {Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston (devices for protecting guide needles in combination with catheters A61M25/0612)} - A61M 5/326: {Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user} - A61M 5/46: having means for controlling depth of insertion - A61M 5/206: {with automatic needle insertion} - A61M 2005/208: {Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin} - A61M 2205/581: by audible feedback - A61M 2205/582: by tactile feedback - A61M 2205/583: by visual feedback - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site. ## Claims ### Claim 1 An auto-injector for administering a dose of a medicament, comprising: a tubular chassis; a drive sub-assembly comprising a tubular carrier slidably arranged relative to the tubular chassis, the tubular carrier adapted to at least partially contain a syringe with a hollow injection needle arranged in a proximal part of the auto-injector, wherein the auto-injector is configured to allow joint translation between the syringe and the tubular carrier; a drive spring; and a plunger comprising a flange for forwarding load of the drive spring to a stopper of the syringe, the plunger comprising a proximal portion extending proximally from the flange and a distal portion extending distally from the flange, the proximal and distal portions being substantially centered about a longitudinal axis of the tubular chassis, an axial length of the proximal portion being larger than an axial length of the distal portion, and a radial distance between the drive spring and the distal portion of the plunger being substantially constant along at least half of an axial length of the distal portion; a trigger button configured to release the drive spring by allowing the distal portion of the plunger to disengage from the tubular carrier by an inward deflection to advance the plunger and the stopper for at least partially delivering the dose of the medicament; a control spring acting between a first collar, biased by the control spring in a proximal direction, and a second collar bearing against a distal end of the control spring; and a cap removably attached to a proximal end of the auto-injector, the auto-injector configured such that a removal of the cap from the auto-injector removes a protective sheath covering a needle of the syringe without causing an axial movement of the syringe, wherein the control spring is configured to move the drive sub-assembly in a distal direction for needle retraction, the first collar is configured to decouple from the tubular carrier and ground a proximal end of the control spring to the tubular chassis, the second collar is allowed to rotate out of a threaded engagement to allow syringe retraction, and the second collar is configured to couple to the tubular carrier, whereby the distal end of the control spring moves the second collar in the distal direction taking the tubular carrier and the syringe with the second collar. ### Claim 2 (depends on 1) The auto-injector according to claim 1, wherein the control spring is a compression and torsion spring. ### Claim 3 (depends on 1) The auto-injector according to claim 1, comprising a tubular case, wherein the cap is attached to a proximal end of the tubular case with the protective sheath in place over the needle. ### Claim 4 (depends on 3) The auto-injector according to claim 3, wherein the cap has a profiled surface mating with a surface on the tubular case so that the cap is pulled off when rotated. ### Claim 5 (depends on 1) The auto-injector according to claim 1, comprising a noise release mechanism comprising a noise component capable of, upon release, generating an audible and/or tactile feedback. ### Claim 6 (depends on 1) The auto-injector according to claim 1, wherein a diameter of an outer surface of the distal portion of the plunger is larger at a proximal-most end of the distal portion compared to a remainder of the distal portion. ### Claim 7 (depends on 1) The auto-injector according to claim 1, wherein the auto-injector is configured to advance the syringe in the proximal direction relative to the tubular chassis for needle insertion. ### Claim 8 (depends on 7) The auto-injector according to claim 7, wherein at least one resilient beam is arranged on the first collar and configured to initiate syringe retraction. ### Claim 9 (depends on 1) The auto-injector according to claim 1, wherein an inner surface of the distal portion of the plunger defines at least one first recess and an outer surface of the distal portion of the plunger defines at least one second recess. ### Claim 10 (depends on 1) The auto-injector according to claim 1, comprising the syringe containing the dose of the medicament, the dose of the medicament comprising a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof. ### Claim 11 An auto-injector for administering a medicament, comprising: a tubular chassis; a drive sub-assembly comprising a tubular carrier slidably arranged relative to the tubular chassis, the tubular carrier adapted to at least partially contain a syringe with a hollow injection needle arranged in a proximal part of the auto-injector, wherein the auto-injector is configured to allow joint translation between the syringe and the tubular carrier; a drive spring; and a plunger comprising a flange for forwarding load of the drive spring to a stopper of the syringe, the plunger comprising a proximal portion extending proximally from the flange and a distal portion extending distally from the flange, the proximal and-distal portions being substantially centered about a longitudinal axis of the tubular chassis, and an axial length of the proximal portion being larger than an axial length of the distal portion; a trigger button configured to release the drive spring by allowing the distal portion of the plunger to disengage from the tubular carrier by an inward deflection to advance the plunger and the stopper for at least partially delivering the medicament; and a control spring configured to bias the tubular carrier in a distal direction, wherein the auto-injector is configured such that after a resilient arm of a first collar has moved relative to the tubular chassis, the control spring is released and moves the tubular carrier and the syringe in the distal direction relative to the tubular chassis. ### Claim 12 (depends on 11) The auto-injector according to claim 11, wherein the auto-injector is configured such that a radial distance between the drive spring and the distal portion of the plunger is substantially constant along at least half of an axial length of the distal portion of the plunger. ### Claim 13 (depends on 11) The auto-injector according to claim 11, wherein the control spring is a compression and torsion spring and has a diameter that is larger than a diameter of the drive spring. ### Claim 14 (depends on 11) The auto-injector according to claim 11, comprising a cap removably attached to a proximal end of the auto-injector, the auto-injector configured such that a removal of the cap from the auto-injector removes a protective sheath covering the hollow injection needle of the syringe without causing an axial movement of the syringe. ### Claim 15 (depends on 14) The auto-injector according to claim 14, wherein the cap is attached to a proximal end of a tubular case of the auto-injector. ### Claim 16 (depends on 15) The auto-injector according to claim 15, wherein the cap has a profiled surface mating with a surface on the tubular case so that the cap is pulled off when rotated. ### Claim 17 (depends on 11) The auto-injector according to claim 11, wherein a diameter of an outer surface of the distal portion of the plunger is larger at a proximal-most end of the distal portion compared to a remainder of the distal portion. ### Claim 18 (depends on 11) The auto-injector according to claim 11, wherein the auto-injector is configured to advance the syringe in a proximal direction relative to the tubular chassis for needle insertion. ### Claim 19 (depends on 11) The auto-injector according to claim 11, wherein an inner surface of the distal portion of the plunger defines at least one first recess and an outer surface of the distal portion of the plunger defines at least one second recess. ### Claim 20 (depends on 11) The auto-injector according to claim 11, comprising the syringe containing the medicament, the medicament comprising a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof. ### Claim 21 An auto-injector for administering a medicament, comprising: a tubular chassis; a tubular carrier slidably arranged relative to the tubular chassis, the tubular carrier adapted to at least partially contain a syringe with a hollow injection needle arranged in a proximal part of the auto-injector, wherein the auto-injector is configured to allow joint translation between the syringe and the tubular carrier; a drive spring; a plunger comprising a flange for forwarding load of the drive spring to a stopper of the syringe, the plunger comprising a proximal portion extending proximally from the flange and a distal portion extending distally from the flange, the proximal and distal portions being substantially centered about a longitudinal axis of the tubular chassis, an axial length of the proximal portion being larger than an axial length of the distal portion, and the drive spring being disposed around the distal portion of the plunger; and a trigger button configured to release the drive spring by allowing the distal portion of the plunger to disengage from the tubular carrier by an inward deflection to advance the plunger and the stopper for at least partially delivering the medicament. ### Claim 22 (depends on 21) The auto-injector according to claim 21, comprising a control spring acting between a first collar, biased by the control spring in a proximal direction, and a second collar bearing against a distal end of the control spring, wherein the control spring is a compression and torsion spring and has a diameter that is larger than a diameter of the drive spring. ### Claim 23 (depends on 22) The auto-injector according to claim 22, wherein the auto-injector is configured such that after a resilient arm of the first collar has moved relative to the tubular chassis, the control spring is released and moves the tubular carrier and the syringe in a distal direction relative to the tubular chassis. ### Claim 24 (depends on 21) The auto-injector according to claim 21, wherein the auto-injector is configured such that a radial distance between the drive spring and the distal portion of the plunger is substantially constant along at least half of an axial length of the distal portion of the plunger. ### Claim 25 (depends on 21) The auto-injector according to claim 21, comprising a cap removably attached to a proximal end of the auto-injector, the auto-injector configured such that a removal of the cap from the auto-injector removes a protective sheath covering the hollow injection needle of the syringe without causing an axial movement of the syringe. ### Claim 26 (depends on 25) The auto-injector according to claim 25, wherein the cap has a profiled surface mating with a surface on a tubular case of the auto-injector so that a rotation of the cap relative to the tubular chassis causes a proximal movement of the cap relative to the tubular chassis. ### Claim 27 (depends on 21) The auto-injector according to claim 21, wherein an inner surface of the distal portion of the plunger defines at least one first recess and an outer surface of the distal portion of the plunger defines at least one second recess. ### Claim 28 (depends on 21) The auto-injector according to claim 21, comprising the syringe at least partially contained in the tubular carrier, the syringe containing the medicament, and the medicament comprising a glucagon-like peptide-1 (GLP-1) or an analogue or derivative thereof. ### Claim 29 An auto-injector for administering a dose of a medicament, comprising: a tubular chassis; a drive sub-assembly comprising a tubular carrier slidably arranged relative to the tubular chassis, the tubular carrier adapted to at least partially contain a syringe with a hollow injection needle arranged in a proximal part of the auto-injector, wherein the auto-injector is configured to allow joint translation between the syringe and the tubular carrier; a drive spring; and a plunger comprising a flange for forwarding load of the drive spring to a stopper of the syringe, the plunger comprising a proximal portion extending proximally from the flange and a distal portion extending distally from the flange, the proximal and distal portions being substantially centered about a longitudinal axis of the tubular chassis, an axial length of the proximal portion being larger than an axial length of the distal portion, and a radial distance between the drive spring and the distal portion of the plunger being substantially constant along at least half of an axial length of the distal portion; a trigger button configured to release the drive spring by allowing the distal portion of the plunger to disengage from the tubular carrier by an inward deflection to advance the plunger and the stopper for at least partially delivering the dose of the medicament; a control spring acting between a first collar, biased by the control spring in a proximal direction, and a second collar bearing against a distal end of the control spring; a cap removably attached to a proximal end of the auto-injector, the auto-injector configured such that a removal of the cap from the auto-injector removes a protective sheath covering the hollow injection needle of the syringe without causing an axial movement of the syringe; and a syringe retraction control mechanism arranged for coupling the distal end of the control spring to the tubular carrier for needle retraction, wherein the control spring is configured to move the drive sub-assembly in a distal direction for needle retraction, the first collar is configured to decouple from the tubular carrier and ground a proximal end of the control spring to the tubular chassis, the second collar is allowed to rotate out of a threaded engagement by the syringe retraction control mechanism to allow syringe retraction, and the second collar is configured to couple to the tubular carrier, whereby the distal end of the control spring moves the second collar in the distal direction taking the tubular carrier and the syringe with the second collar. ### Claim 30 (depends on 29) The auto-injector according to claim 29, wherein at least one resilient beam is arranged on the first collar and configured to initiate the syringe retraction control mechanism.