# US 12,214,149 B2 · Applicator system containing a microneedle array which comprises an active ingredient for wound healing > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,214,149 B2 - Document ID: US12214149B2 - Status: Granted - Kind: B2 - Application number: 16/634,592 - Filed: 2018-08-04 - Published: 2020-06-18 - Granted: 2025-02-04 - Earliest claimed: 2017-08-04 - Assignees: LTS Lohmann Therapie-Systeme AG - Applicants: Lts Lohmann Therapie-Systeme AG - Inventors: Stefan Henke; Karsten Heuser - Web page: https://patentgrep.com/patent/US12214149B2 ## CPC - A61M 37/0015: {by using microneedles} - A61K 9/0021: {Intradermal administration, e.g. through microneedle arrays or needleless injectors} - A61K 31/164: of a carboxylic acid with an aminoalcohol, e.g. ceramides - A61K 31/17: having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine (isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64) - A61K 31/728: Hyaluronic acid - A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree - A61K 36/886: Aloeaceae (Aloe family), e.g. aloe vera - A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] - A61M 2037/0023: {Drug applicators using microneedles} - A61M 2037/0061: {Methods for using microneedles} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The invention relates to an applicator system comprising a microneedle array and to the use thereof for the intradermal delivery of active ingredients, and in particular of medicinal drugs, wherein this microneedle array is suitable for penetrating the skin of humans or animals and includes at least one active ingredient for wound healing. ## Claims ### Claim 1 An applicator system comprising a microneedle array for use for the intradermal delivery of a first active ingredient, the applicator system comprising: a plurality of microneedles on a carrier, wherein the microneedles are made of a polymer matrix in which at least one second active ingredient for wound healing is integrated or incorporated; a trigger mechanism; and at least one reservoir for storing the first active ingredient, the reservoir being in connection to the microneedles; and wherein the first active ingredient is different from the at least one second active ingredient for wound healing, and the first active ingredient is a medicinal drug; wherein the at least one second active ingredient for wound healing is selected from the group consisting of dexpanthenol, collagen, hyaluronic acid, and combinations thereof; and wherein the polymer of the polymer matrix is selected from the group consisting of polylactides, polyglycolides, polylactide-co-glycolides, polyanhydrides, poly(ortho)esters, polyurethanes, polybutyric acids, polyvaleric acids, polylactide-co-caprolactones, polycarbonates, polyesters, polyvinyl chloride, polyacrylamides, cycloolefin (co)polymers, polymethacrylates, and thermoplastics. ### Claim 2 (depends on 1) The applicator system according to claim 1, wherein the microneedle array is planar. ### Claim 3 (depends on 1) The applicator system according to claim 1, wherein the density of the microneedles on a carrier is 5 to 5,000 pieces/cm2. ### Claim 4 (depends on 1) The applicator system according to claim 1, wherein the at least one second active ingredient for wound healing is integrated or incorporated in the polymer matrix in an amount of 150 to 200 mg/cm2. ### Claim 5 (depends on 1) The applicator system according to claim 1, wherein the microneedle array comprises fixation means. ### Claim 6 (depends on 1) The applicator system according to claim 1, wherein the microneedle array comprises fixation means which is selected from the group consisting of adhesive strip, patch, band, elastic band, rubber and strap. ### Claim 7 (depends on 1) The applicator system according to claim 1, wherein the first active ingredient is stored in the reservoir. ### Claim 8 (depends on 1) The applicator system according to claim 1, wherein the reservoir is a flexible bag or a balloon. ### Claim 9 (depends on 1) The applicator system according to claim 1, wherein the carrier is flexible and planar and the plurality of microneedles are integrated into the flexible planar carrier. ### Claim 10 (depends on 9) The applicator system according to claim 9, wherein the applicator system comprises at least one reservoir containing the first active ingredient. ### Claim 11 An applicator system comprising a microneedle array for the intradermal delivery of a first active ingredient, the applicator system comprising: a plurality of microneedles on a carrier, wherein the microneedles are made of a polymer matrix in which at least one second active ingredient for wound healing is integrated or incorporated; a trigger mechanism; and at least one reservoir in connection with the microneedles; and wherein the at least one reservoir contains the first active ingredient; wherein the first active ingredient is different from the at least one second active ingredient for wound healing, and the first active ingredient is a medicinal drug; wherein the at least one second active ingredient for wound healing is selected from the group consisting of dexpanthenol, collagen, hyaluronic acid, and combinations thereof; and wherein the polymer of the polymer matrix is selected from the group consisting of polylactides, polyglycolides, polylactide-co-glycolides, polyanhydrides, poly(ortho)esters, polyurethanes, polybutyric acids, polyvaleric acids, polylactide-co-caprolactones, polycarbonates, polyesters, polyvinyl chloride, polyacrylamides, cycloolefin (co)polymers, polymethacrylates, and thermoplastics. ### Claim 12 (depends on 11) The applicator system according to claim 11, wherein the reservoir is a flexible bag or a balloon.