Back to results
US 12,214,086 B2Granted
Surface functionalized, host-guest polymer nano-assemblies and methods thereof
AssigneeUniversity of Massachusetts
InventorsSankaran Thayumanavan, Jiaming Zhuang, Hui Wang
Life of this patent
Estimating the term…
Abstract
The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
Claims14
A polymer-based nanoparticle having a vesicular structure stabilized by intraparticular crosslinking inside the vesicular structure, wherein the polymer comprises the monomer unit:
- wherein Z3 is
- wherein Z′ is selected from O or NH;
- R3 is selected from H, C1-C12 alkyl group, or halogen;
- RL3 is CR4, wherein R4 is H, C1-C12 alkyl group or halogen;
- RF comprises C(O)(NH)CH2CH2NH2 or C(O)NH(oligoethylene glycol);
- Rx is a crosslinking group capable of inter- or intra-molecular crosslinking or an inter- or intra-molecularly crosslinked group, selected from pyridinyl disulfide and thiol;
- and
- r is an integer from about 10 to about 1000.
5 more elements
Dependencies are inferred from the claim text.