Tablet dosage formulations of oleyl phosphocholine

A process for making an olelyl phosphocholine (OlPC) containing granulate, said process comprising a blending step, a hot melt extrusion step and a milling step,

• wherein the blending step comprises preparing a granulation mixture of olelyl phosphocholine and granulation excipients, wherein said granulation excipients comprise at least a spacer, an antioxidant and a disintegrant, and optionally a binder and/or a lubricant;
• wherein the hot melt extrusion step comprises preparing an extrudate by heating said granulation mixture at a temperature of at least 50° C. and below 90° C. and extrudating said heated granulation mixture;
• wherein the milling step comprises cooling said extrudate and milling said cooled extrudate to obtain a milled extrudate;
• wherein no solvent is added during the process for granulation,
• wherein the concentration of oleyl phosphocholine in the milled extrudate is between 10 and 50 weight percent,
• wherein, if a binder is added as a granulation excipient, the concentration of the binder in the milled extrudate is between 10 and 50 weight percent,
• wherein, if a lubricant is added as a granulation excipient, the concentration of the lubricant in the milled extrudate is between 1 and 20 weight percent,
• wherein the concentration of the antioxidant in the milled extrudate is between 0.05 and 5 weight percent,
• wherein the concentration of the disintegrant in the milled extrudate is between 1 and 20 weight percent,
• wherein the concentration of the spacer in the milled extrudate is between 10 and 50 weight percent, and
• wherein the concentrations are relative to the milled extrudate.