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US 12,214,072 B2Granted
Chewable tablet and method of preparing the same
AssigneeAmbrosia Supherb Ltd.
InventorSharon Raz
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Abstract
The present disclosure provides chewable tablets comprising (i) a compressed core including a bioactive molecule; (ii) a protective layer over said compressed core, and (iii) one or more soft-coating layers over said protective layer, each soft coating layer comprises gum base powder; wherein the protective layer comprises water-insoluble cellulose based polymers, preferably ethyl cellulose based polymer.
Claims22
A chewable tablet comprising
- a compressed core including a bioactive molecule;
- a protective layer over the compressed core,
- wherein the protective layer comprises a water-insoluble cellulose based polymer;
- and
- two or more soft-coating layers over the said protective layer,
- wherein each soft coating layer comprises gum base powder,
- wherein an innermost layer of the two or more soft coating layers is bound to the protective layer,
- wherein the chewable tablet comprises a sufficient amount of the water-insoluble cellulose based polymer in the protective layer to result in, when tested after 12 months of storage at 25° C., the chewable tablet not disintegrating 24 hours after insertion into water.
5 more elements
A method of preparing a chewable tablet comprising:
- (a) applying a protective material onto a compressed tablet comprising a bioactive molecule, the protective material comprising a water-insoluble cellulose based polymer to form a protective layer on said compressed tablet;
- (b) applying two or more soft-coating layers onto said protective layer, said two or more soft coating layers comprising gum base powder, wherein an innermost layer of said two or more soft coating layers is applied to said protective layer,
- wherein the chewable tablet comprises a sufficient amount of the water-insoluble cellulose based polymer in the protective layer to result in, when tested after 12 months of storage at 25° C., the chewable tablet not disintegrating 24 hours after insertion into water.
A chewable tablet comprising:
- a compressed core including a bioactive molecule;
- a protective layer over the compressed core,
- wherein the protective layer comprises water-insoluble cellulose based polymer;
- and
- two or more soft-coating layers over the protective layer,
- wherein each soft coating layer comprises gum base powder,
- wherein an innermost layer of the two or more soft coating layers is directly bound to the protective layer,
- wherein the water-insoluble cellulose based polymer comprises ethyl cellulose in an amount, out of a total amount of polymers in the protective layer, that is not less than 40% by weight.
5 more elements
Dependencies are inferred from the claim text.