# US 12,214,066 B2 · Hair care compositions

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- Number: US 12,214,066 B2
- Document ID: US12214066B2
- Status: Granted
- Kind: B2
- Application number: 16/603,280
- Filed: 2018-04-04
- Published: 2020-04-23
- Granted: 2025-02-04
- Earliest claimed: 2017-04-07
- Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem; Smart Resilin Ltd.
- Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.; Smart Resilin Ltd.
- Inventors: Oded Shoseyov; Roni Shalev; Sigal Baruch-Sharon; Tal Ben Shalom; Liron Nuttman-Nesial
- Web page: https://patentgrep.com/patent/US12214066B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/447: {containing sulfur}
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/736: {Chitin; Chitosan; Derivatives thereof}
- A61K 8/988: {Honey; Royal jelly, Propolis}
- A61Q 5/04: Preparations for permanent waving or straightening the hair
- A61Q 5/06: Preparations for styling the hair, e.g. by temporary shaping or colouring
- A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns
- A61K 2800/654: The particulate/core comprising macromolecular material
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided are methods, compositions and kits employing cellulose nanocrystals for hair-straightening treatment. Also provided are methods, compositions and kits employing a resilin, for hair-straightening treatment and/or for maintenance of straightened hair following a hair-straightening treatment.

## Claims

### Claim 1

A method of straightening hair, the method comprising:
applying to the hair cysteine, sodium metabisulfite or a combination thereof to thereby obtain cleaved disulfide bonds in the hair;
applying arginine or chitosan to the hair, having cleaved disulfide bonds and heat treating the hair;
subsequently to heat treating the hair, applying to the hair a formulation containing cellulose nanocrystals (CNC) bonded to cellulose binding domain (CBD)-modified resilin in a non-covalent interaction; and
subsequent to applying the formulation containing the CNC, applying heat and pressure to the hair, to cause hair straightening without causing damage to hair,
thereby straightening the hair.

### Claim 2 (depends on 1)

The method of claim 1, further comprising contacting said hair, having been treated with said formulation containing said CNC bonded to CBD-modified resilin in a non-covalent interaction, with a cross-linking agent capable of cross-linking cellulose nanocrystals.

### Claim 3 (depends on 1)

The method of claim 1, comprising applying a further amount of CBD-modified resilin to the hair subsequently to the hair straightening.

### Claim 4 (depends on 3)

The method of claim 3, wherein said applying the further amount of CBD-modified resilin is effected at least one day subsequently to the hair straightening.

### Claim 5 (depends on 4)

The method of claim 4, wherein said applying the further amount of CBD-modified resilin is effected at least one week after the hair straightening.

### Claim 6 (depends on 4)

The method of claim 4, wherein said applying the further amount of CBD-modified resilin is effected during a time period in a range of from one week to two years after hair straightening.

### Claim 7 (depends on 3)

The method of claim 3, wherein said applying the further amount of CBD-modified resilin is effected on at least two different days.

### Claim 8 (depends on 7)

The method of claim 7, wherein said applying the further amount of CBD-modified resilin is effected on at least 5 different days.