Nanoparticle platform for antibody and vaccine delivery
AssigneesThe Hospital for Sick Children, The Governing Council of the University of Toronto
InventorsJean-Philippe Julien, Taylor Sicard, Anthony Semesi, Bebhinn Treanor, Tiantian Zhao, Edurne Rujas Diez
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Abstract
A fusion protein comprises a nanocage monomer; and an antibody or fragment thereof linked to the nanocage monomer, the antibody or fragment thereof comprising a first member of a binding pair; wherein a plurality of the fusion proteins self-assemble to form a nanocage in which a plurality of the antibodies or fragments thereof decorate the exterior surface of the nanocage, whereby the first member of the binding pair is exposed for interacting with a second member of a binding pair.
Claims7
A fusion protein comprising an antibody fragment consisting of a single-chain Fc (scFc), wherein the antibody fragment is fused to a nanocage monomer via a linker.
Dependencies are inferred from the claim text.