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US 12,214,044 B2Granted
Factor VIII zwitterionic polymer conjugates
AssigneeKodiak Sciences Inc.
InventorsStephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
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Abstract
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
Claims15
A compound having the following formula:
- wherein s is 1-20;
- p is 1 to 12;
- R2 is selected from the group consisting of alkyl, substituted alkyl, alkylene, alkoxy, carboxyalkyl, haloalkyl, cycloalkyl, cyclic alkyl ether, alkenyl, alkenylene, alkynyl, alkynylene, cycloalkylene, heterocycloalkyl, heterocycloalkylene, aryl, arylene, arylene-oxy, heteroaryl, amino, amido or any combination thereof;
- and
- R3 is
- wherein R4, R5, and R6 are the same or different and are selected from the group consisting of:
- and
- wherein Z is polymer, the polymer is synthesized with a monomer selected from the group consisting of:
- wherein
- R7 is H or C1-6 alkyl, ZW is a zwitterion, and t is 1 to 6.
7 more elements
Dependencies are inferred from the claim text.