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US 12,214,007 B2Granted
Fusion protein including BDNF
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsHiroyuki Sonoda, Kenichi Takahashi
Life of this patent
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Abstract
The present invention provides a fusion protein of BDNF and an anti-human transferrin receptor antibody, in which in a heavy chain variable region of the antibody, (a) CDR1 includes an amino acid sequence of SEQ ID NO: 66 or SEQ ID NO: 67, (b) CDR2 includes an amino acid sequence of SEQ ID NO: 13 or SEQ ID NO: 14, and (c) CDR3 includes an amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 16.
Claims41
A fusion protein of human brain-derived neurotrophic factor (human BDNF) and an anti-human transferrin receptor antibody, selected from (1) or (2) below:
- (1) the fusion protein wherein in a heavy chain variable region of the antibody,
- (a) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 66,
- (b) CDR2 comprises the amino acid sequence of SEQ ID NO:
- 13,
- (c) CDR3 comprises the amino acid sequence of SEQ ID NO:
- 15, and
- (d) framework region 3 comprises the amino acid sequence of SEQ ID NO:
- 68,
- wherein in a light chain variable region of the antibody,
- (a) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 6,
- (b) CDR2 comprises the amino acid sequence of SEQ ID NO:
- 8, and
- (c) CDR3 comprises the amino acid sequence of SEQ ID NO:
- 10, and
- wherein the human BDNF binds to the N-terminus of the heavy chain of the antibody via a linker;
- (2) the fusion protein wherein in a heavy chain variable region of the antibody,
- (a) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 67,
- (b) CDR2 comprises the amino acid sequence of SEQ ID NO:
- 14,
- (c) CDR3 comprises the amino acid sequence of SEQ ID NO:
- 16, and
- (d) framework region 3 comprises the amino acid sequence of SEQ ID NO:
- 68, and
- wherein in a light chain variable region of the antibody,
- (a) CDR1 comprises the amino acid sequence of SEQ ID NO:
- 7,
- (b) CDR2 comprises the amino acid sequence of SEQ ID NO:
- 9, and
- (c) CDR3 comprises the amino acid sequence of SEQ ID NO:
- 10, and
- wherein the human BDNF binds to the N-terminus of the heavy chain of the antibody via a linker.
31 more elements
Dependencies are inferred from the claim text.