# US 12,213,992 B2 · Iron containing composition and use thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,213,992 B2 - Document ID: US12213992B2 - Status: Granted - Kind: B2 - Application number: 17/272,756 - Filed: 2019-09-05 - Published: 2021-07-08 - Granted: 2025-02-04 - Earliest claimed: 2018-09-05 - Assignees: Renapharma AB - Applicants: Renapharma AB - Inventors: Robert Hider; Peter Geisser - Web page: https://patentgrep.com/patent/US12213992B2 ## CPC - A61K 33/26: Iron; Compounds thereof - A23D 7/0053: {Compositions other than spreads} - A23L 33/12: Fatty acids or derivatives thereof - A23L 33/16: Inorganic salts, minerals or trace elements - A23L 33/165: Complexes or chelates - A61K 9/10: Dispersions; Emulsions - A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} - A61K 31/225: Polycarboxylic acids - A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms - A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters - A61P 7/06: Antianaemics - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23D: EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS (preservation thereof A23B20/00; production, refinement or preservation of animal or vegetable fats or oils C11B, C11C) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract A composition comprising an iron salt of a C8 to C24 fatty acid, a citric acid ester of mono- and/or diglyceride or a mixture of citric acid esters of mono- and/or diglyceride and optionally a fatty acid or a mixture of fatty acids, and a method for preparing such a composition. The composition is useful as a medicament for the treatment and prophylaxis of iron deficiency, as a dietary supplement, and as a food additive. ## Claims ### Claim 1 A composition comprising (i) an iron salt of a C12-C18 fatty acid; (ii) a citric acid ester of mono- and/or diglyceride or a mixture of citric acid esters of mono- and/or diglyceride; and (iii) a fatty acid or a salt thereof, or a mixture of fatty acids or fatty acid salts; wherein the composition comprises from 5 to 50% by weight of component (i), from 50 to 95% by weight of component (ii), and up to 20% by weight of component (iii); wherein the citric acid ester of mono- and/or diglyceride or mixture of citric acid esters of mono- and/or diglyceride comprises mono- and/or diglycerides of one or more C8-C24 fatty acids; and wherein component (iii) comprises one or more C8-C24 fatty acids or salts thereof. ### Claim 2 (depends on 1) The composition of claim 1, wherein the fatty acid is a saturated fatty acid. ### Claim 3 (depends on 1) The composition of claim 1, wherein the citric acid ester of mono- and/or diglyceride or mixture of citric acid esters of mono- and/or diglyceride comprises a monoesterified citric acid ester of mono- and/or diglyceride or mixture of monoesterified citric acid esters of mono- and/or diglyceride. ### Claim 4 (depends on 1) The composition of claim 1, wherein the weight ratio of component (ii) to component (i) is from 10:1 to 1:1. ### Claim 5 (depends on 1) A method for the treatment or prophylaxis of iron deficiency or a disorder associated with iron deficiency, the method comprising administering the composition of claim 1 to a mammal in need of such treatment. ### Claim 6 (depends on 5) The method of claim 5, wherein the treatment is by oral administration of said composition. ### Claim 7 (depends on 1) A pharmaceutical formulation comprising a therapeutically effective amount of a composition according to claim 1, and optionally a pharmaceutically acceptable excipient. ### Claim 8 (depends on 7) The pharmaceutical formulation of claim 7, wherein said composition constitutes from 1 to 99% by weight of the formulation. ### Claim 9 (depends on 7) The pharmaceutical formulation of claim 7, for oral administration. ### Claim 10 (depends on 7) The pharmaceutical formulation of claim 7, in the form of a hard capsule, a soft capsule, or a liquid. ### Claim 11 (depends on 1) A dietary supplement comprising the composition of claim 1. ### Claim 12 (depends on 1) A food additive comprising the composition according to claim 1. ### Claim 13 (depends on 1) A foodstuff comprising the composition according to claim 1. ### Claim 14 (depends on 1) A method for the preparation of an iron containing composition as set forth in claim 1, the method comprising: admixing components (i), (ii), and (iii); adding water and optionally a basifying agent; and processing the mixture to obtain a dispersion. ### Claim 15 (depends on 1) The composition of claim 1, wherein the weight ratio of component (ii) to component (i) is from 6:1 to 1:1.