# US 12,213,991 B2 · Preparations for controlled-release of hypochlorous acid

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- Number: US 12,213,991 B2
- Document ID: US12213991B2
- Status: Granted
- Kind: B2
- Application number: 17/838,866
- Filed: 2022-06-13
- Published: 2022-10-13
- Granted: 2025-02-04
- Earliest claimed: 2012-02-17
- Assignees: Wiab Water Innovation AB
- Applicants: Wiab Water Innovation AB
- Inventors: Geir Hermod Almås
- Web page: https://patentgrep.com/patent/US12213991B2

## CPC

- A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- C01B 11/04: Hypochlorous acid
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}

## Abstract

Provided are anti-microbial compositions that include an aqueous solution of hypochlorous acid encapsulated in a nanoparticle that allows for controlled release of hypochlorous acid. Also provided are methods of making and using such compositions.

## Claims

### Claim 1

A method of making an anti-microbial composition comprising an aqueous solution of hypochlorous acid encapsulated in a nanoparticle, the method comprising the steps of:
mixing together in water in a chamber from which air has been purged a compound that generates a proton (H+) in water and a compound that generates a hypochlorite anion (OCl−) in water, thereby to produce an air-free aqueous solution of hypochlorous acid; and
encapsulating the air-free aqueous solution of hypochlorous acid and an anti-metabolic agent selected from a group consisting of zinc, copper, and silver in a nanoparticle.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition that generates the hypochlorite anion and the compound that generates the proton are introduced to the water sequentially.

### Claim 3 (depends on 1)

The method of claim 1, wherein the compound that generates the hypochlorite anion is selected from the group consisting of sodium hypochlorite (NaOCl), Mg(OCl)2, and Ca(OCl)2.

### Claim 4 (depends on 1)

The method of claim 1, wherein the method is performed without use of chorine gas or use of electrolysis.

### Claim 5 (depends on 1)

The method of claim 1, wherein the aqueous solution of hypochlorous acid has a pH from about 4.5 to about 7.5.

### Claim 6 (depends on 1)

The method of claim 1, wherein the compound that generates proton in water is acetic acid.

### Claim 7 (depends on 1)

The method of claim 1, wherein the nanoparticle comprises a polymer, liposome, or hydrogel.

### Claim 8

A method of making an anti-microbial composition comprising an aqueous solution of hypochlorous acid encapsulated in a nanoparticle, the method comprising the steps of:
producing an aqueous solution of hypochlorous acid by performing in an air-free environment and under pressure the steps of:
introducing hydrochloric acid (HCl) to a flow of water;
turbulently mixing the HCl with the flowing water in a first mixing device from which air has been purged;
introducing sodium hypochlorite (NaOCl) to the water after the water has exited the first mixing device; and
turbulently mixing the NaOCl with the flowing water in a second mixing device from which air has been purged, thereby producing an aqueous solution of hypochlorous acid (HOCl); and
encapsulating the aqueous solution of hypochlorous acid and an anti-metabolic agent selected from a group consisting of zinc, copper, and silver in a nanoparticle.