# US 12,213,986 B1 · Compositions and methods for treating epilepsy

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- Number: US 12,213,986 B1
- Document ID: US12213986B1
- Status: Granted
- Kind: B1
- Application number: 18/417,252
- Filed: 2024-01-19
- Published: 2025-01-30
- Granted: 2025-02-04
- Earliest claimed: 2023-07-24
- Applicants: Poviva Corp
- Inventors: John Docherty; Christopher Andrew Bunka
- Web page: https://patentgrep.com/patent/US12213986B1

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/2009: {Inorganic compounds}
- A61K 9/2013: {Organic compounds, e.g. phospholipids, fats}
- A61K 9/205: {Polysaccharides, e.g. alginate, gums; Cyclodextrin}
- A61K 9/2068: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/2013)}
- A61K 9/4858: {Organic compounds}
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61P 15/10: for impotence
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.

## Claims

### Claim 1

A composition consisting of:
a) from about 35 mg to about 150 mg of CBD oil extract containing at least about 98% by weight of cannabidiol;
b) from about 70 mg to about 300 mg of olive oil;
c) from about 3 mg to about 13 mg of deoxycholic acid;
d) from about 135 mg to about 560 mg of mannitol, colloidal silicon dioxide, or a mixture thereof.

### Claim 2 (depends on 1)

The composition according to claim 1, consisting of from about 35 mg to about 120 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 3 (depends on 1)

The composition according to claim 1, consisting of from about 35 mg to about 95 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 4 (depends on 1)

The composition according to claim 1, consisting of from about 35 mg to about 75 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 5 (depends on 1)

The composition according to claim 1, consisting of from about 75 mg to about 150 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 6 (depends on 1)

The composition according to claim 1, consisting of from about 75 mg to about 120 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 7 (depends on 1)

The composition according to claim 1, consisting of from about 75 mg to about 95 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 8 (depends on 1)

The composition according to claim 1, consisting of from about 95 mg to about 120 mg of CBD oil extract containing at least about 98% by weight of cannabidiol.

### Claim 9 (depends on 1)

The composition according to claim 1, consisting of from about 70 mg to about 250 mg of olive oil.

### Claim 10 (depends on 1)

The composition according to claim 1, consisting of from about 70 mg to about 190 mg of olive oil.

### Claim 11 (depends on 1)

The composition according to claim 1, consisting of from about 150 mg to about 300 mg of olive oil.

### Claim 12 (depends on 1)

The composition according to claim 1, consisting of from about 90 mg to about 300 mg of olive oil.

### Claim 13 (depends on 1)

The composition according to claim 1, consisting of from about 70 mg to about 240 mg by weight of olive oil.

### Claim 14 (depends on 1)

The composition according to claim 1, consisting of from about 70 mg to about 190 mg by weight of olive oil.

### Claim 15 (depends on 1)

The composition according to claim 1, consisting of from about 150 mg to about 300 mg by weight of olive oil.

### Claim 16 (depends on 1)

The composition according to claim 1, consisting of from about 190 mg to about 300 mg by weight of olive oil.

### Claim 17 (depends on 1)

The composition according to claim 1, consisting of from about 135 mg to about 440 mg of a carrier selected from the group consisting of from mannitol, colloidal silicon dioxide, and a mixture thereof.

### Claim 18 (depends on 1)

The composition according to claim 1, consisting of from about 135 mg to about 360 mg of a carrier selected from the group consisting of from mannitol, colloidal silicon dioxide, and a mixture thereof.

### Claim 19 (depends on 1)

The composition according to claim 1, consisting of from about 135 mg to about 280 mg of a carrier selected from the group consisting of from mannitol, colloidal silicon dioxide, and a mixture thereof.

### Claim 20 (depends on 1)

The composition according to claim 1, consisting of from about 280 mg to about 560 mg of a carrier selected from the group consisting of from mannitol, colloidal silicon dioxide, and a mixture thereof.

### Claim 21 (depends on 1)

The composition according to claim 1, consisting of about 67 mg of mannitol and about 68 mg of colloidal silicon dioxide.

### Claim 22 (depends on 1)

The composition according to claim 1, consisting of about 139 mg of mannitol and about 141 mg of colloidal silicon dioxide.

### Claim 23 (depends on 1)

The composition according to claim 1, consisting of about 139 mg of mannitol and about 141 mg of colloidal silicon dioxide.

### Claim 24 (depends on 1)

The composition according to claim 1, consisting of about 143 mg of mannitol and about 144 mg of colloidal silicon dioxide.
